Results 31 to 40 of about 1,043 (175)

Multi‐Omics Analysis of Human Blood Cells Reveals Unique Features of Age‐Associated Type 2 CD8 Memory T Cells

Aging Cell, Volume 25, Issue 2, February 2026.
Aging drives the accumulation of CXCR3‐ central memory CD8 T cells that exhibit Th2‐like transcriptional and epigenetic programs. These cells display a pathogenic Th2‐skewed profile and are associated with age‐related diseases, including asthma, chronic liver disease, and type 2 diabetes.
Hiroyuki Matsui, Marlene Cervantes, Mir M. Khalid, Alan Tomusiak, Varun Dwaraka, Jorge Landgrave‐Gomez, Prasanna Vadhana Ashok Kumaar, Qingwen Chen, Jessica Lasky‐Su, Jake Stone, Ritesh Tiwari, Ryan Kwok, Shuntaro Ichikawa, Benjamin D. Ambrose, Rebeccah R. Riley, Genesis Vega Hormazabal, Ariel Adkisson‐Floro, Andreea Cristina Alexandru, Ryan Smith, Birgit Schilling, Herbert G. Kasler, Eric Verdin   +21 more
wiley   +1 more source

Protein Target Highlights in CASP16: Insights From the Structure Providers

Proteins: Structure, Function, and Bioinformatics, Volume 94, Issue 1, Page 25-50, January 2026.
ABSTRACT This article presents an in‐depth analysis of selected CASP16 targets, with a focus on their biological and functional significance. The authors highlight the most relevant features of the target proteins and discuss how well these were reproduced in the submitted predictions.
Leila T. Alexander, Océane M. Follonier, Andriy Kryshtafovych, Kim Abesamis, Sabrina Bibi‐Triki, Henry G. Box, Cécile Breyton, Françoise Bringel, Loic Carrique, Alessio d'Acapito, Gang Dong, Rebecca DuBois, Deborah Fass, Juliana Martinez Fiesco, Daniel R. Fox, Jonathan M. Grimes, Rhys Grinter, Matthew Jenkins, Roman Kamyshinsky, Jeremy R. Keown, Gerald Lackner, Michael Lammers, Shiheng Liu, Andrew L. Lovering, Tomas Malinauskas, Benoît Masquida, Gottfried J. Palm, Christian Siebold, Tiantian Su, Ping Zhang, Z. Hong Zhou, Krzysztof Fidelis, Maya Topf, John Moult, Torsten Schwede   +34 more
wiley   +1 more source

Factors associated with the quality of life of subjects with Parkinson's disease and burden on their caregivers

Neurología (English Edition), 2015
Introduction: Parkinson's disease affects the quality of life of the individual with the disease in addition to creating a burden on the caregiver. Factors related to these effects include motor and non-motor aspects of the disease, as well as traits ...
M. Rodríguez-Violante, A. Camacho-Ordoñez, A. Cervantes-Arriaga, P. González-Latapí, S. Velázquez-Osuna   +4 more
doaj   +1 more source

Urinary Incontinence Among Adults With Systemic Lupus Erythematosus

ACR Open Rheumatology, Volume 7, Issue 12, December 2025.
Objective The epidemiology of urinary incontinence (UI) in systemic lupus erythematosus (SLE) remains understudied. We estimated the prevalence and life burden of UI and examined associations of UI with SLE activity and disease damage in a population‐based US SLE cohort.
Gabriel Salazar, Scott Bauer, Courtney Hoge, S. Sam Lim, Jinoos Yazdany, Laura Plantinga   +5 more
wiley   +1 more source

Caracterización de los pacientes con enfermedad de Parkinson

Acta Médica del Centro, 2021
Introducción: la enfermedad de Parkinson es un proceso degenerativo complejo del sistema nervioso central de inicio insidioso progresivo y desarrollo lento que es consecuencia de una lesión idiopática en el sistema extrapiramidal.
Lázaro Aurelio Vázquez Gómez, Liovesky Madrigal Mora, Ana María Mederos Herrera, Yanet Valdés Morales   +3 more
doaj  

Prospective Longitudinal Cohort of Argentinean Patients with Progressive Supranuclear Palsy: A Platform for Epidemiological and Translational Research [PDF]

Alzheimers Dement
Abstract Background Progressive supranuclear palsy (PSP) and corticobasal syndrome (CBS) are two neurodegenerative disorders that manifest disabling postural instability, parkinsonism, cognitive impairment and falls with brain neurofibrillary tangle lesions containing 4‐repeat tau protein. The prevalence is 6/100,000 inhabitants but estimated only from
Couto B, Pinto M, Avale M, Falzone T, Gershanik O, Chade A, Mizraji G, Gonzalez‐Toledo M, Peralta M, Gomez‐Arevalo G, Mezmezian M, Marras C, Sevlever G.   +12 more
europepmc   +2 more sources

Cognitive profiles at presentation and subsequent cognitive decline and quality of life in Parkinson's disease

Alzheimer's &Dementia, Volume 21, Issue 12, December 2025.
Abstract INTRODUCTION Currently, our ability to predict cognitive decline in Parkinson's disease is limited. METHODS In 234 dementia‐free PD patients, cognitive profiles at baseline were determined using cluster analysis and longitudinal associations with global cognitive z‐score, health‐related quality of life (HR‐QoL), caregiver burden, and risk of ...
Saira S. Mirza, Sarah Duff‐Canning, Mark Mapstone, Susan Fox, Sandra E. Black, Malcolm A. Binns, David P. Breen, Keera N. Fishman, David A. Grimes, Anthony E. Lang, Brian Levine, Paula M. McLaughlin, Angela K. Troyer, Mario Masellis, Connie Marras   +14 more
wiley   +1 more source

Implicaciones de la microbiota intestinal en la etiología y terapéutica de la enfermedad de Parkinson

Revista Habanera de Ciencias Médicas, 2018
Introducción: Es reconocido que pacientes con la Enfermedad de Parkinson suelen manifestar trastornos gastro-intestinales, y que la microbiota intestinal modula la gravedad de la presentación clínica de esta enfermedad.
Luis Enrique Almaguer Mederos, Wilmer Martínez Martínez, David Guach Hevia   +2 more
doaj  

Locus coeruleus‐entorhinal cortex tract integrity is linked to plasma tau and glial fibrillary acidic protein

Alzheimer's &Dementia, Volume 21, Issue 12, December 2025.
Abstract INTRODUCTION Pretangle tau inclusions from the locus coeruleus (LC) are hypothesized to propagate to the entorhinal cortex (EC) via neuron‐to‐neuron transmission along its projections. The lower integrity of the LC‐EC pathway accompanying Alzheimer's disease (AD) pathology is supported by post mortem studies, but in vivo evidence remains ...
Yuliya Patsyuk, Maxime Van Egroo, Elise Beckers, Elouise A. Koops, Nicholas J. Ashton, Shorena Janelidze, Kaj Blennow, Oskar Hansson, Henrik Zetterberg, Benedikt A. Poser, Heidi I. L. Jacobs   +10 more
wiley   +1 more source

El espacio de teatro en el Taller de Parkinson

Revista +E, 2015
Presentamos el espacio de teatro en el Taller de Parkinson, sus objetivos, metodología y resultados. Este taller es una iniciativa de un grupo interdisciplinario de profesionales (actualmente programa estable de extensión de la Facultad de Ciencias ...
Vanina Dubois, María de los Ángeles Bacigalupe   +1 more
doaj   +1 more source