Results 111 to 120 of about 3,928,365 (313)

The role of lipid metabolism in neuronal senescence

open access: yesFEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari   +2 more
wiley   +1 more source

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

open access: yesFEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman   +4 more
wiley   +1 more source

Development of human monoclonal antibodies against TARM1 by yeast display

open access: yesFEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe   +5 more
wiley   +1 more source

“Shouting into a canyon” or “A golden goose Egg”: Understanding teachers’ emotional experience in distance learning through creative metaphor

open access: yesMethods in Psychology
Distance learning was a unique struggle for teachers, who reported some of the highest levels of stress among any professionals in the U.S. This study investigates teachers' emotional experience and creative development in COVID-19 pandemic distance ...
Ross C. Anderson, Mari Livie
doaj   +1 more source

Deconstructing Engagement: A First Generation Report on the ArtsSmarts Student Engagement Questionnaire [PDF]

open access: yes, 2007
During the school year 2006-2007, ArtsSmarts representatives collaborated with Karen Hume to design a questionnaire to measure students' engagement before and after ArtsSmarts programs. The questionnaire was administered to a large number of students who
Saad Chahine
core  

Matrix metalloproteinase‐9 regulates cell adhesion and membrane protrusive activity of ovarian cancer cells

open access: yesFEBS Open Bio, EarlyView.
Matrix metalloproteinase‐9 (MMP9) drives ovarian cancer progression. Using MMP9‐null cells (M9‐KO) created from ovarian cancer cells, we found MMP9 loss did not block Epidermal Growth Factor (EGF)‐driven E‐cadherin dissolution or EMT but delayed and reduced EGF‐driven membrane protrusions. Transient MMP9 re‐expression drove membrane protrusion.
Claire Strauel   +8 more
wiley   +1 more source

Termination of architect's engagement [PDF]

open access: yes, 2008
Issuance of Certificate Completion and Compliance (CCC) by Professional Architect has made the role of Professional Architect become more important.
Zolkafli @ Zulkifli, Umi Kalsum
core  

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

open access: yesFEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Family at the Center [PDF]

open access: yes, 2015
To better understand how family engagement supports school readiness in Los Angeles County, The David and Lucile Packard Foundation and the LA Partnership for Early Childhood Investment convened an advisory group of early childhood leaders and ...

core  

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