Results 11 to 20 of about 52,720 (208)

Sensory nerves in the spotlight of the stem cell niche. [PDF]

Stem Cells Transl Med, 2021
Schematic illustration summarizing the findings from genetic deletion of EP4 specifically from sensory nerve fibers in the bone marrow mesenchymal stem cell niche. Abstract Niches are specialized tissue microenvironments that control stem cells functioning.
Picoli CC, Costa AC, Rocha BGS, Silva WN, Santos GSP, Prazeres PHDM, Costa PAC, Oropeza A, da Silva RA, Azevedo VAC, Resende RR, Cunha TM, Mintz A, Birbrair A.   +13 more
europepmc   +2 more sources

Assessing the combined effect of surface topography and substrate rigidity in human bone marrow stem cell cultures. [PDF]

Eng Life Sci, 2022
Abstract The combined effect of surface topography and substrate rigidity in stem cell cultures is still under‐investigated, especially when biodegradable polymers are used. Herein, we assessed human bone marrow stem cell response on aliphatic polyester substrates as a function of anisotropic grooved topography and rigidity (7 and 12 kPa).
Ribeiro S, Pugliese E, Korntner SH, Fernandes EM, Gomes ME, Reis RL, O'Riordan A, Bayon Y, Zeugolis DI.   +8 more
europepmc   +2 more sources

Ablation of sensory nerves favours melanoma progression. [PDF]

J Cell Mol Med, 2020
Abstract The tumour mass is composed not only of heterogeneous neoplastic cells, but also a variety of other components that may affect cancer cells behaviour. The lack of detailed knowledge about all the constituents of the tumour microenvironment restricts the design of effective treatments.
Prazeres PHDM, Leonel C, Silva WN, Rocha BGS, Santos GSP, Costa AC, Picoli CC, Sena IFG, Gonçalves WA, Vieira MS, Costa PAC, Campos LMCC, Lopes MTP, Costa MR, Resende RR, Cunha TM, Mintz A, Birbrair A.   +17 more
europepmc   +2 more sources

Dopamine-loaded nanoparticle systems circumvent the blood–brain barrier restoring motor function in mouse model for Parkinson’s Disease

Scientific Reports, 2021
Parkinson's disease (PD) is a progressive and chronic neurodegenerative disease of the central nervous system. Early treatment for PD is efficient; however, long-term systemic medication commonly leads to deleterious side-effects.
Victoria Monge-Fuentes, Andréia Biolchi Mayer, Marcos Robalinho Lima, Luiza Ribeiro Geraldes, Larissa Nepomuceno Zanotto, Karla Graziella Moreira, Olimpia Paschoal Martins, Henrique Luís Piva, Maria Sueli Soares Felipe, Andre Correa Amaral, Anamélia Lorenzetti Bocca, Antonio Claudio Tedesco, Márcia Renata Mortari   +12 more
doaj   +1 more source

Biossíntese e caracterização de nanocelulose bacteriana para engenharia de tecidos [PDF]

Matéria (Rio de Janeiro), 2018
RESUMO Queimaduras causam lesões do revestimento epitelial, a partir de um agente externo, podendo variar desde uma pequena bolha flictena até formas mais graves, capazes de desencadear respostas sistêmicas. O uso de curativos contendo substâncias cicatrizantes e antimicrobianas é uma opção para terapia local.
Fischer, Michele Roberta, Garcia, Michele Cristina Formolo, Nogueira, André Lourenço, Porto, Luismar Marques, Schneider, Andréa Lima dos Santos, Pezzin, Ana Paula Testa   +5 more
openaire   +3 more sources

Biocompatibilidade do gel de quitosana associado ao glicerol fosfato na reparação de defeitos ósseos induzidos experimentalmente no rádio de coelhos (Oryctolagus cuniculus) [PDF]

Arquivo Brasileiro de Medicina Veterinária e Zootecnia, 2020
RESUMO A engenharia de tecidos caracteriza-se como ciência interdisciplinar, a qual vem desenvolvendo biomateriais para a regeneração do tecido ósseo no âmbito das medicinas humana e veterinária.
B.W. Minto, C.P. Borsaro, M. Nobile, L.P. Coelho, G.G. Franco, F.Y.K. Kawamoto, M.G.N. Campos, L.G.G.G. Dias   +7 more
doaj   +1 more source

Expressão transiente do gene gus, sob regulação de quatro promotores, em diferentes tecidos de mamoeiro (Carica papaya L.) e videira (Vitis sp.) [PDF]

Revista Brasileira de Fruticultura, 2002
O mamoeiro (Carica papaya L.) e a videira (Vitis vinifera L.) destacam-se entre as fruteiras produzidas no Brasil por serem plantadas em quase todo o território nacional e apresentarem importância econômica e social.
Adelar Almeida Pinto, Marly Catarina Felipe Coelho, Manoel Teixeira Souza Jr, Miguel Pedro Guerra   +3 more
doaj   +1 more source

Staphylococcus epidermidis role in the skin microenvironment

Journal of Cellular and Molecular Medicine, Volume 23, Issue 9, Page 5949-5955, September 2019., 2019
Abstract Wound healing is a complex dynamic physiological process in response to cutaneous destructive stimuli that aims to restore the cutaneous’ barrier role. Deciphering the underlying mechanistic details that contribute to wound healing will create novel therapeutic strategies for skin repair.
Caroline Leonel, Isadora F. G. Sena, Walison N. Silva, Pedro H. D. M. Prazeres, Gabriel R. Fernandes, Pamela Mancha Agresti, Mariana Martins Drumond, Akiva Mintz, Vasco A. C. Azevedo, Alexander Birbrair   +9 more
wiley   +1 more source

Research within the curricula of Biomedical Engineering Degree: two study cases

Saúde & Tecnologia, 2014
Desde os anos oitenta que os avanços das ciências básicas e das ciências da engenharia têm dado um impulso sem precedentes à investigação médica, o que criou as condições para a afirmação da Engenharia Biomédica como ramo autónomo da Engenharia.
J. Seabra, J. Sanches, F. Viola, A. C. Dinis, J. Mendanha, L. M. Pedro, P. Brogueira, M. T. Peña   +7 more
doaj   +1 more source

Glioblastoma‐activated pericytes support tumor growth via immunosuppression

Cancer Medicine, Volume 7, Issue 4, Page 1232-1239, April 2018., 2018
Glioblastoma‐activated pericytes develop an immunosuppressive phenotype, reducing T‐cell activation through the induction of an anti‐inflammatory response. Pericytes support glioblastoma growth in vitro and in vivo. Abstract Glioblastoma multiforme is the most common and aggressive primary brain tumor, with an extremely poor prognosis.
Isadora F. G. Sena, Ana E. Paiva, Pedro H. D. M. Prazeres, Patrick O. Azevedo, Luiza Lousado, Sujit K. Bhutia, Alla B. Salmina, Akiva Mintz, Alexander Birbrair   +8 more
wiley   +1 more source