Optical Investigation of the Influence of In-cylinder Flow and Mixture Inhomogeneity on Cyclic Variability in a Direct-Injection Spark Ignition Engine [PDF]
, 2022 Judith Laichter, Sebastian A. Kaiser
openalex +1 more source
Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine
Molecular Oncology, EarlyView.The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu +18 more
wiley +1 more source
Investigation of cylinder deactivation and variable valve actuation on gasoline engine performance [PDF]
, 2014 Increasingly stringent regulations on gasoline engine fuel consumption and exhaust emissions require additional technology integration such as Cylinder Deactivation (CDA) and Variable valve actuation (VVA) to improve part load engine efficiency.
Kuruppu, C, Pesiridis, A, Rajoo, S
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A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
Modeling of a heavy duty diesel engine to ease complex optimization decisions [PDF]
, 2014 Engine optimization becomes more difficult every day, more and more limits regarding emissions of noxious components have to be met. Considering heavy duty marine engines such as the 6DZC from ABC there are several important instances: IMO III reduces ...
Verhelst, Sebastian +2 more
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Evaluation of Motorcycles’ Handling and Stability Under Slalom Conditions
MachinesHandling and stability are crucial performance characteristics of motorcycles. However, handling and stability are always in opposition, which leads to difficulty in evaluating the comprehensive performance of a motorcycle.
Haoxuan Sun +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source
Method for improving the fuel efficiency of a gas turbine engine [PDF]
, 1985 An energy recovery system is provided for an aircraft gas turbine engine of the type in which some of the pneumatic energy developed by the engine is made available to support systems such as an environmental control system.
Coffinberry, G. A.
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Radiation environment for rendezvous and docking with nuclear rockets [PDF]
, 1972 Radiation environment data for the NERVA engine are provided which may be utilized in estimating radiation exposures associated with various space maneuvers.
Lindsey, B. A. +2 more
core +2 more sources
Journal of Aeronautical Materials, 2018 Selective laser melting (SLM) was used to fabricate Hastelloy X alloy. The characteristics of grains and precipitates in Hastelloy X alloy processed by heat treatments (HT) and hot isostatic pressing (HIP) was analyzed.
ZHANG Yongzhi +5 more
doaj +1 more source