Results 81 to 90 of about 231,070 (269)

Determination of the Quantitative Characteristics of the Engine of a Household Power Plant when Using Generator Gas as an Alternative Fuel [PDF]

Problems of the Regional Energetics, 2017
The relevance of the study is due to the need to study the feasibility of replacing traditional fuel with alternative types (generator gas) when using a household power plant. The purpose of the study is to obtain the value of a small-displacement engine
Plotnikov S. A., Buzikov Sh. V., Kartashevich A. N., Zubakin A. S.   +3 more
doaj  

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Compensating cooling on the suction surface of the blade by the jets of the film holes on the endwall

Case Studies in Thermal Engineering
The coolant ejected from the film holes on the gill region of the blade deflects to the blade tip in the action of the cascade passage vortices, resulting in the local film cooling failure on the suction surface near the endwall. This paper introduces an
Changyu Zhao, Junyu Zhu, Wei Zhang, Zhiqi Zhao, Guangchao Li, Chun Li   +5 more
doaj   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Analysis of Oil-Gas Two-Phase Flow Characteristics of Bearing Chamber Sealing System with Baffle Structure

Lubricants
In order to explore the influence of baffle structure on the oil–gas two-phase flow and leakage characteristics of aero-engine bearing chamber sealing systems, based on the VOF two-phase flow model, this paper systematically carried out a transient ...
Guozhe Ren, Rui Wang, Mingzhang Wang, Huan Zhao, Wenfeng Xu   +4 more
doaj   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Engineering and reverse-engineering morality.

, 2021
Recent years have witnessed a burst of progress on building formal models of moral decision-making. In psychology, neuroscience and philosophy, the goal has been to “reverse-engineer” the principles of human morality. Meanwhile, in AI ethics, the goal has been to engineer systems that can make moral decisions, in some ways inspired by how humans do ...
Levine, Sydney, Cushman, Fiery, Rahwan, Iyad, Tenenbaum, Josh   +3 more
openaire   +1 more source

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

FEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes, Maria X. Isaksen, Frida Julbø, Manohar Pradhan, Andreas Kleppe, Sepp De Raedt, Ole‐Johan Skrede, Turid Torheim, John Arne Nesheim, Hans Martin Mohn, Hanne A. Askautrud, Karolina Cyll, Wanja Kildal, Emma Rewcastle, Melinda Lillesand, Vebjørn Kvikstad, Emiel Janssen, Robert Jones, Odd Terje Brustugun, Bjørn Brennhovd, Erik Skaaheim Haug, Lill‐Tove Rasmussen Busund, Elin Richardsen, Sigve Andersen, Tom Dønnem, Kristina Lindemann, Gunnar Kristensen, Neil A. Shepherd, Marco Novelli, Knut Liestøl, David Kerr, Håvard E. Danielsen, Tarjei S. Hveem   +32 more
wiley   +1 more source

A Numerical Investigation of the Effects of the Fuel Injection Pressure and Nozzle Hole Diameter on Natural Gas–Diesel Dual-Fuel Combustion Characteristics

Energies
Natural gas–diesel dual-fuel (NDDF) engines can reduce harmful emissions while maintaining diesel-like efficiency. However, under low-load conditions, they suffer from high methane (CH4) emissions, reduced combustion stability, and lower thermal ...
Murat Durmaz, Selma Ergin
doaj   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source