Results 61 to 70 of about 738,621 (291)
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Investigating the Effect of Engine Lubricant Viscosity on Engine Friction and Fuel Economy of a Diesel Engine [PDF]
Fuel economy is affected, both by fuel and engine lubricant quality. Engine lubricant quality plays a vital role in reduction of fuel consumption by effective reduction of friction between the contact surfaces of engine parts (piston ring assembly ...
Singh, Devendra
core +3 more sources
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
The role of semiotic engineering in software engineering [PDF]
Proceedings of the 5th International Workshop on Theory-Oriented Software Engineering, 2016 Semiotic engineering is based upon the semiotic theory of Human-Computer Interaction (HCI), which focuses on communication between designers and users. Semiotic engineering tries to improve users’ interpretation through meta- communication and emphasizes that designers should play the role of legitimate interlocutors in interactive systems.
Vahdat Abdelzad +2 more
openaire +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
Model engine data sheets and operating instructions, E - F, ca. 1950, 1991-1993, 1997, 1999
, 1950 Operating instructions and parts list for the Feeney 4-Cycle model ...
Feeny Engine Company
core
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Nihon Kikai Gakkai ronbunshu, 2016 Bioethanol can be used as alternative fuel for an internal combustion engine. However, the price of bioethanol per calorific value is generally higher than that of gasoline.
Yuzo SHIRAKAWA +2 more
doaj +1 more source
Tribology Online, 2020 In view of irregular abnormal cavitation noise in main bearing of engine under the dynamic load from engine spindle, this paper is devoted to finding effective factors that can reduce this cavitation noise.
Xu Liu +4 more
doaj +1 more source