Results 71 to 80 of about 1,792,111 (309)

Termites: Soil engineers for ecological engineering

Comptes Rendus. Biologies, 2019
This communication assesses advances in our knowledge of the beneficial influences of termites on ecosystem functioning and services. Termites are amongst the main macroinvertebrate decomposers in arid and semi-arid environments and exert additional impacts through the creation of biostructures (mounds, galleries, sheetings, etc.) with ...
Jouquet, Pascal, Harit, Ajay, Cheik, Sougueh, Traoré, Saran, Bottinelli, Nicolas   +4 more
openaire   +3 more sources

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Design method and the development of the low-temperature-difference indirect heating Stirling engine

Nihon Kikai Gakkai ronbunshu, 2018
Low-temperature-difference indirect heating Stirling engine is the most suitable device for a small-scale wood biomass combined heat and power. To design this type of Stirling engine, conventional design method is not sufficient for optimizing working ...
Makoto TAKEUCHI, Shinji SUZUKI, Yutaka ABE   +2 more
doaj   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Knowledge Engineering for Non-engineers [PDF]

, 2010
This paper presents one approach for the innovative organization training for business analysts in developing enterprise ontologies. The underlying teaching framework is pursuing a methodology that will aid the process of knowledge structuring and practical ontology design, with emphasis on visual techniques.
openaire   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Analysis of possibilities of high-speed prototyping technology in hot section manufacturing

MATEC Web of Conferences, 2018
The article is devoted to the exercising of a trial technological process for the manufacture of gas turbine engine (GTE) hot sections by the example of a solid-cast nozzle block.
Balaykin Andrey V., Vdovin Roman A., Dobryshkina Elena M.   +2 more
doaj   +1 more source

A study on the relationship between vehicle operating conditions and NOx emission characteristics [PDF]

E3S Web of Conferences
To address the challenges faced by vehicles during actual operation when passing through traffic lights or intersections, where rapid changes in operating conditions can lead to a decrease in SCR efficiency and an increase in NOx emissions, this study ...
Xia Ran, Wang Yu, Feng Yifang, Chen Tao, Qin Jing   +4 more
doaj   +1 more source