Results 51 to 60 of about 233,252 (269)

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Application of Large Eddy Simulation in the process of the Multi-Physics Field Coupling in a Combustion Chamber

MATEC Web of Conferences, 2015
Numerical simulation is the main method to solve turbulence problems. As one of the three methods which are commonly used in large-eddy simulation model (LES) is the most effective and promising research method. The basic idea of large-eddy simulation is
Xu Rang-Shu, Wang Kai, Xu Long, Yu Xin
doaj   +1 more source

Effect of hydrogen direct injection timing on ammonia combustion in a marine engine: A numerical study [PDF]

E3S Web of Conferences
The injection timing of hydrogen in an ammonia-hydrogen fueled marine engine significantly affects combustion performance and emissions. This study aims to identify the optimal hydrogen direct injection timing window.
Li Xiao, Li Hongmei, Ju Dehao, Zhang Wenzheng, Zheng Liang, Jiang Yuqi   +5 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

A review of recent advances in the application of machine learning algorithms for gas turbine combustion

Propulsion and Energy
With the rapid advancement of computing power and significant progress in machine learning (ML) algorithms, ML has shown immense potential across a wide range of fields, particularly in simulation, experimental analysis, and condition monitoring.
Da Mo, Yuzhen Lin, Yixiong Liu, Yuchen Wang, Ziyu Qin, Xiao Han   +5 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Acoustic mode detection in an engine nacelle with a scaled rig fan

Advances in Aerodynamics
Acquiring acoustic modes with high quality data in large-scale nacelles is quite challenging in the engine industry because of the complex configuration, high flow speed, tremendous number of acoustic modes, and some other extraordinary interference.
Kangle Xu, Yiang Lyu, Lijuan Feng, Changchun Liu, Jiayuan Ji   +4 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source