Results 51 to 60 of about 231,070 (269)
Design method and the development of the low-temperature-difference indirect heating Stirling engine
Nihon Kikai Gakkai ronbunshu, 2018 Low-temperature-difference indirect heating Stirling engine is the most suitable device for a small-scale wood biomass combined heat and power. To design this type of Stirling engine, conventional design method is not sufficient for optimizing working ...
Makoto TAKEUCHI +2 more
doaj +1 more source
Phosphoinositides and inositol phosphates as molecular glues
FEBS Letters, EarlyView.Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry +9 more
wiley +1 more source
Trends in Genetics, 2014 Allosteric proteins have great potential in synthetic biology, but our limited understanding of the molecular underpinnings of allostery has hindered the development of designer molecules, including transcription factors with new DNA-binding or ligand-binding specificities that respond appropriately to inducers.
Raman, Srivatsan +4 more
openaire +4 more sources
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
The role of semiotic engineering in software engineering [PDF]
Proceedings of the 5th International Workshop on Theory-Oriented Software Engineering, 2016 Semiotic engineering is based upon the semiotic theory of Human-Computer Interaction (HCI), which focuses on communication between designers and users. Semiotic engineering tries to improve users’ interpretation through meta- communication and emphasizes that designers should play the role of legitimate interlocutors in interactive systems.
Vahdat Abdelzad +2 more
openaire +1 more source
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Analysis of possibilities of high-speed prototyping technology in hot section manufacturing
MATEC Web of Conferences, 2018 The article is devoted to the exercising of a trial technological process for the manufacture of gas turbine engine (GTE) hot sections by the example of a solid-cast nozzle block.
Balaykin Andrey V. +2 more
doaj +1 more source
Effect of Diesel Fuel-Coconut Oil-Butanol Blends on Operational Parameters of Diesel Engine
Energies, 2020 The global concentration of greenhouse gasses in the atmosphere is increasing as well as the emissions of harmful pollutants. Utilization of liquid biofuels in combustion engines helps to reduce these negative effects. For diesel engines, the most common
Jakub Čedík +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source