Results 41 to 50 of about 231,070 (269)

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Application of Large Eddy Simulation in the process of the Multi-Physics Field Coupling in a Combustion Chamber

MATEC Web of Conferences, 2015
Numerical simulation is the main method to solve turbulence problems. As one of the three methods which are commonly used in large-eddy simulation model (LES) is the most effective and promising research method. The basic idea of large-eddy simulation is
Xu Rang-Shu, Wang Kai, Xu Long, Yu Xin
doaj   +1 more source

Effect of hydrogen direct injection timing on ammonia combustion in a marine engine: A numerical study [PDF]

E3S Web of Conferences
The injection timing of hydrogen in an ammonia-hydrogen fueled marine engine significantly affects combustion performance and emissions. This study aims to identify the optimal hydrogen direct injection timing window.
Li Xiao, Li Hongmei, Ju Dehao, Zhang Wenzheng, Zheng Liang, Jiang Yuqi   +5 more
doaj   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

A review of recent advances in the application of machine learning algorithms for gas turbine combustion

Propulsion and Energy
With the rapid advancement of computing power and significant progress in machine learning (ML) algorithms, ML has shown immense potential across a wide range of fields, particularly in simulation, experimental analysis, and condition monitoring.
Da Mo, Yuzhen Lin, Yixiong Liu, Yuchen Wang, Ziyu Qin, Xiao Han   +5 more
doaj   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Acoustic mode detection in an engine nacelle with a scaled rig fan

Advances in Aerodynamics
Acquiring acoustic modes with high quality data in large-scale nacelles is quite challenging in the engine industry because of the complex configuration, high flow speed, tremendous number of acoustic modes, and some other extraordinary interference.
Kangle Xu, Yiang Lyu, Lijuan Feng, Changchun Liu, Jiayuan Ji   +4 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source