Results 41 to 50 of about 930,385 (313)

Gaussian Process Model-Based Performance Uncertainty Quantification of a Typical Turboshaft Engine

Applied Sciences, 2021
The gas turbine engine is a widely used thermodynamic system for aircraft. The demand for quantifying the uncertainty of engine performance is increasing due to the expectation of reliable engine performance design.
Xuejun Liu, Hailong Tang, Xin Zhang, Min Chen   +3 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Investigating the impact of abrasive tool wear on surface topography and microstructure evolution in polished GH4169G alloy through experiments and multi-scale simulations

Journal of Materials Research and Technology
This study investigates the influence of abrasive tool wear on the surface topography and microstructure evolution of GH4169G during polishing, combining experiments and simulations to assess surface functionality.
Rui Yang, Xiaojun Lin, Youwei Chen, Tao Zhao   +3 more
doaj   +1 more source

JT9D jet engine performance deterioration [PDF]

, 1978
The analytical techniques utilized to examine the effects of flight loads and engine operating conditions on performance deterioration are presented.
Jay, A., Sallee, G. P., Todd, E. S.
core   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Reduced integral scheme of damaged divided back stress elasto plastic model based on full implicit algorithm

Nihon Kikai Gakkai ronbunshu, 2015
The purpose of this study is formulating the reduced integration method of damage elasto plastic constitutive model with divided back stress based on full implicit framework.
Shogo SANNOMARU, Shigenobu OKAZAWA, Satoyuki TANAKA   +2 more
doaj   +1 more source

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Current status and prospects of aviation remanufacturing technology based on cold spray

Hangkong gongcheng jinzhan
Cold spray additive manufacturing technology，with its unique "solid-state deposition" process characteristics，has shown great application potential in the repair and remanufacturing of damaged aerospace structures.
CHI Yada, CUI Minchao, LUO Ming, LI Wenya, ZHANG Dinghua   +4 more
doaj   +1 more source