Results 51 to 60 of about 9,256,798 (287)

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Investigation on Wear Evolution Behavior of Pyramid Belt in Grinding of GH4169 Superalloy

Journal of Manufacturing and Materials Processing
Owing to its unique pyramid-shaped stacked abrasive structure, the pyramid belt pro-vides fine and uniform grinding performance, making it increasingly attractive for precision grinding applications.
Zhijian Tao, Rui Xu, Songjiaming Liu, Xin Huang, Zhao Zhang, Junde Qi, Dinghua Zhang   +6 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Water Injection Effects on the Performance and Emission Characteristics of a CI Engine Operating with Biodiesel [PDF]

, 2012
Biodiesel is one of the most promising renewable, alternative and environmentally friendly biofuels that can be used in diesel engine without any need for any modification in the engine.
Gu, Fengshou, Ball, Andrew, Ball, A. D., A.D. Ball, Gu, F., F. Gu, Tesfa, Belachew, Tesfa, B., Mishra, Rakesh, B. Tesfa, R. Mishra, Mishra, R.; id_orcid   +11 more
core   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Engineering the Performance [PDF]

Social Studies of Science, 2004
At the dawn of sound recording, recordists were mechanical engineers whose only training was on the job. As the recording industry grew more sophisticated, so did the technology used to make records, yet the need for recording engineers to use craft skill and tacit knowledge in their work did not diminish.
openaire   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Investigating the impact of abrasive tool wear on surface topography and microstructure evolution in polished GH4169G alloy through experiments and multi-scale simulations

Journal of Materials Research and Technology
This study investigates the influence of abrasive tool wear on the surface topography and microstructure evolution of GH4169G during polishing, combining experiments and simulations to assess surface functionality.
Rui Yang, Xiaojun Lin, Youwei Chen, Tao Zhao   +3 more
doaj   +1 more source

Gas-turbine diagnostics using artificial neural-networks for a high bypass ratio military turbofan engine [PDF]

, 2004
The Tristar aircraft, operated by the Royal Air Force, fly many thousands of hours per year in the transport and air-to-air refuelling roles. A large amount of engine data is recorded for each of the Rolls-Royce RB211-524B4 engines: it is used to aid ...
Singh, Riti, Probert, Sydney D., Ogaji, Stephen O. T., Joly, R. B.   +3 more
core   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source