Results 51 to 60 of about 174,121 (317)
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
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Nihon Kikai Gakkai ronbunshu, 2015 The purpose of this study is formulating the reduced integration method of damage elasto plastic constitutive model with divided back stress based on full implicit framework.
Shogo SANNOMARU +2 more
doaj +1 more source
Evaluating the performance engineering process [PDF]
Proceedings of the 2nd international workshop on Software and performance, 2000 This contribution presents a model for process improvement in the area of performance engineering, which is called performance engineering maturity model. The use of this model allows the evaluation of the level of integration and application of performance engineering.
Andreas Schmietendorf +2 more
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Multi-disciplinary conceptual design of future jet engine systems [PDF]
, 2010 This thesis describes various aspects of the development of a multi-disciplinary aero engine conceptual design tool, TERA2020 (Techno-economic, Environmental and Risk Assessment for 2020), based on an explicit algorithm that considers: engine ...
Kyprianidis, Konstantinos G.
core
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
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COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
The Resurgence of Software Performance Engineering [PDF]
Proceedings of the 30th on Symposium on Parallelism in Algorithms and Architectures, 2018 Today, most application developers write code without much regard for how quickly it will run. Moreover, once the code is written, it is rare for it to be reengineered to run faster. But two technology trends of historic proportions are instigating a resurgence in software performance engineering, the art of making code run fast.
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The Future of Software Performance Engineering [PDF]
Future of Software Engineering (FOSE '07), 2007 Performance is a pervasive quality of software systems; everything affects it, from the software itself to all underlying layers, such as operating system, middleware, hardware, communication networks, etc. Software Performance Engineering encompasses efforts to describe and improve performance, with two distinct approaches: an early-cycle predictive ...
C. Murray Woodside +2 more
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Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
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Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source