Results 51 to 60 of about 12,557,310 (317)

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

Current status and prospects of aviation remanufacturing technology based on cold spray

Hangkong gongcheng jinzhan
Cold spray additive manufacturing technology，with its unique "solid-state deposition" process characteristics，has shown great application potential in the repair and remanufacturing of damaged aerospace structures.
CHI Yada, CUI Minchao, LUO Ming, LI Wenya, ZHANG Dinghua   +4 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Acute dermal toxicity study of new, used and laboratory aged aircraft engine oils

Toxicology Reports, 2019
There is little data available on toxicity levels of used aircraft engine oils relative to their unused (new) versions. This study was conducted to determine if new engine oils and their used versions have the potential to induce dermal irritation ...
Isaie Sibomana, Neal A. Good, Patrick T. Hellman, Lewis Rosado, David R. Mattie   +4 more
doaj   +1 more source

The Resurgence of Software Performance Engineering [PDF]

Proceedings of the 30th on Symposium on Parallelism in Algorithms and Architectures, 2018
Today, most application developers write code without much regard for how quickly it will run. Moreover, once the code is written, it is rare for it to be reengineered to run faster. But two technology trends of historic proportions are instigating a resurgence in software performance engineering, the art of making code run fast.
openaire   +1 more source

The Future of Software Performance Engineering [PDF]

Future of Software Engineering (FOSE '07), 2007
Performance is a pervasive quality of software systems; everything affects it, from the software itself to all underlying layers, such as operating system, middleware, hardware, communication networks, etc. Software Performance Engineering encompasses efforts to describe and improve performance, with two distinct approaches: an early-cycle predictive ...
C. Murray Woodside, Greg Franks, Dorina C. Petriu   +2 more
openaire   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Comparative study on machinability and surface integrity of γ-TiAl alloy in laser assisted milling

Journal of Materials Research and Technology
γ-TiAl alloy, as a typical difficult-to-cut material, is considered to have great potential in aero-engine manufacturing. However, it is difficult to achieve high-quality processing of γ-TiAl alloy using traditional cutting processes, due to the room ...
Yada Chi, Zexuan Dong, Minchao Cui, Chenwei Shan, Yifeng Xiong, Dinghua Zhang, Ming Luo   +6 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source