Results 71 to 80 of about 930,385 (313)

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Optimization of process parameters for polishing aero-engine blade with abrasive cloth wheel considering spindle vibration and polished roughness

Scientific Reports
The vibration of machine tool spindle is very important for machining. Firstly, in order to explore the relationship between spindle vibration and process parameters, the spindle vibration acceleration when polishing aero-engine blade was measured, and ...
Chao Xian, De Liu, Hongmin Xin
doaj   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Precipitation mechanism of dispersed carbide in a gear carburizing layer and its effect on properties

Engineering Reports
Heat treatment is carried out on 20MnCr5 gear steel using a cycle carburizing process. The dispersed carbide precipitation mechanism in the carburized layer of 20MnCr5 gear steel is revealed, and the metallographic organization, microhardness, wear ...
Liang Tan, Jiqing Tan, Qiping Lei, Shengwen Hou, Hua Zhong   +4 more
doaj   +1 more source

Inlet Reynolds number and temperature effects on the steady-state performance of a TFE731-2 turbofan engine [PDF]

Effects of varying engine inlet Reynolds number index (0.75, 0.50, 0.25, and 0.12) and temperature (289 and 244 K) on a TFE731-2 turbofan engine were evaluated.
Bobula, G. A., Lottig, R. A.
core   +1 more source

Integrated control system for a gas turbine engine [PDF]

, 1981
A control system for a turbofan engine receives signals from a number of engine sensors and from the engine operator, and generates control signals. One control signal regulates the fan exhaust nozzle area in order to control inlet throat Mach number to ...
Beitler, R. S., Cornett, J. E., Marvin, I. E., Saunders, A. A., Jr.   +3 more
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Effect of ultrasonic vibration-assisted milling on surface quality of carbon fiber reinforced polymer

Journal of Materials Research and Technology
This paper studies the effect and mechanisms of ultrasonic vibration-assisted machining on the surface quality of carbon fiber reinforced polymer (CFRP), based on the kinematic characteristics of ultrasonic vibration-assisted milling.
Yukun Zhang, Junxue Ren, Jinhua Zhou
doaj   +1 more source