Results 71 to 80 of about 12,557,310 (317)

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Precipitation mechanism of dispersed carbide in a gear carburizing layer and its effect on properties

Engineering Reports
Heat treatment is carried out on 20MnCr5 gear steel using a cycle carburizing process. The dispersed carbide precipitation mechanism in the carburized layer of 20MnCr5 gear steel is revealed, and the metallographic organization, microhardness, wear ...
Liang Tan, Jiqing Tan, Qiping Lei, Shengwen Hou, Hua Zhong   +4 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

T-S Fuzzy Model Based H-Infinity Control for 7-DoF Automobile Electrohydraulic Active Suspension System

Journal of Control Science and Engineering, 2017
This paper presents a double loop controller for a 7-DoF automobile electrohydraulic active suspension via T-S fuzzy modelling technique. The outer loop controller employs a modified H-infinity feedback control based on a T-S fuzzy model to provide the ...
Chenyu Zhou, Qiang Yu, Xuan Zhao, Guohua Zhu   +3 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Effect of ultrasonic vibration-assisted milling on surface quality of carbon fiber reinforced polymer

Journal of Materials Research and Technology
This paper studies the effect and mechanisms of ultrasonic vibration-assisted machining on the surface quality of carbon fiber reinforced polymer (CFRP), based on the kinematic characteristics of ultrasonic vibration-assisted milling.
Yukun Zhang, Junxue Ren, Jinhua Zhou
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Thermal Management Optimization of Air Transport Racks Based on a Hybrid Framework

Applied Sciences
With the development of avionics systems towards high integration and high power density, the thermal management of electronic equipment in ATR chassis is facing severe challenges, and the extreme aviation environment further exacerbates the difficulty ...
Biao Xie, Changfeng Yao, Liang Tan, Jiangyu Guo, Jian Wang, Hui Zhang, Juntong Tao, Jia Liu   +7 more
doaj   +1 more source

Effect of surface roughness on erosion wear of turboshaft engine compressor blades [PDF]

Mechanical Sciences
When a turboshaft engine operates in a sand-laden environment, it is prone to erosive wear, which leads to the continuous evolution of surface roughness on compressor blades and consequently alters particle impact behaviour.
D. Luo, G. Bin, A. Ball, F. Gu, H. Miao, C. Li, A. Hamood, W. Yuan   +7 more
doaj   +1 more source