Results 71 to 80 of about 9,256,798 (287)

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Comparative study on machinability and surface integrity of γ-TiAl alloy in laser assisted milling

Journal of Materials Research and Technology
γ-TiAl alloy, as a typical difficult-to-cut material, is considered to have great potential in aero-engine manufacturing. However, it is difficult to achieve high-quality processing of γ-TiAl alloy using traditional cutting processes, due to the room ...
Yada Chi, Zexuan Dong, Minchao Cui, Chenwei Shan, Yifeng Xiong, Dinghua Zhang, Ming Luo   +6 more
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

Data-Driven Comprehensive Error Prediction Method for Multistage Machining of Thin-Walled Blades

Engineered Science
The machining accuracy of thin-walled blades significantly impacts the performance of aeroengines. Existing methods for predicting manufacturing deformation of thin-walled blades often focus on the single-stage machining process and single type of error,
Rui Zhang, Jinhua Zhou, Junxue Ren, Qi Qi, Yongjia Xu   +4 more
doaj   +1 more source

L‐aspartate oxidase provides new insights into fumarate reduction in anaerobic darkness in Synechocystis sp. PCC6803

FEBS Letters, EarlyView.
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil, Jeffrey A. Hawkes, Cecilia Blikstad, Pia Lindberg   +3 more
wiley   +1 more source

A novel configuration for single-crystal superalloy hollow blade manufacturing based on shell/core integral mold

Journal of Materials Research and Technology
Shell/core integral mold fabricated by additive manufacturing possess high shell/core bonding strength, which is promising to improve the dimensional accuracy and integrity of single-crystal (SX) hollow blade while improving the manufacturing efficiency.
Binqiang Wang, Zhexu Li, Kun Bu, Zhongliang Lu, Jiawei Zhang, Sheng Mou, Shengjie Ren, Haoyu Zhao   +7 more
doaj   +1 more source

Acute dermal toxicity study of new, used and laboratory aged aircraft engine oils

Toxicology Reports, 2019
There is little data available on toxicity levels of used aircraft engine oils relative to their unused (new) versions. This study was conducted to determine if new engine oils and their used versions have the potential to induce dermal irritation ...
Isaie Sibomana, Neal A. Good, Patrick T. Hellman, Lewis Rosado, David R. Mattie   +4 more
doaj   +1 more source

Artificial molecular machines and motors—Design and control of nanoscale motion

FEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source