Results 81 to 90 of about 9,256,798 (287)

Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis

FEBS Letters, EarlyView.
This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng, Shen‐Shin Chang, Feng‐Wei Chen, Ying‐Chieh Su, Thanh Phuong Nguyen, Yu‐Wei Hsiao, Jhih‐Ying Chi, Hsin‐Yin Liang, Ju‐Ming Wang   +8 more
wiley   +1 more source

Optimization of process parameters for polishing aero-engine blade with abrasive cloth wheel considering spindle vibration and polished roughness

Scientific Reports
The vibration of machine tool spindle is very important for machining. Firstly, in order to explore the relationship between spindle vibration and process parameters, the spindle vibration acceleration when polishing aero-engine blade was measured, and ...
Chao Xian, De Liu, Hongmin Xin
doaj   +1 more source

Evolution mechanisms of the scratch-induced elastoplastic stress fields and crack damage in γ-TiAl alloys

Journal of Materials Research and Technology
γ-TiAl alloys are extensively utilized in aero-engine turbine blades due to their exceptional physical and mechanical properties. However, the damage mechanisms during the machining of γ-TiAl alloys remain unclear, primarily due to the complexities in ...
Zhaoqing Zhang, Kaining Shi, Yaoyao Shi, Huhu Li, Danni Lu, Yujie Kuang, Jiacheng Liu   +6 more
doaj   +1 more source

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Unlocking the potential of cell‐permeable nanobodies for intracellular applications

FEBS Letters, EarlyView.
This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés, Luise Franz, Christian P.R. Hackenberger   +2 more
wiley   +1 more source

Two Combustor Engine for Military Applications [PDF]

, 2009
The key requirements for military aircraft are high survivability and mission success rate: the former will “exponentially” increase the latter. The survivability of the aircraft depends crucially on its performance and energy signatures, to which its
Soon, Lee Aik
core   +3 more sources

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Precipitation mechanism of dispersed carbide in a gear carburizing layer and its effect on properties

Engineering Reports
Heat treatment is carried out on 20MnCr5 gear steel using a cycle carburizing process. The dispersed carbide precipitation mechanism in the carburized layer of 20MnCr5 gear steel is revealed, and the metallographic organization, microhardness, wear ...
Liang Tan, Jiqing Tan, Qiping Lei, Shengwen Hou, Hua Zhong   +4 more
doaj   +1 more source

Simulation and parametric modeling of residual stress field in shot peening of GH4169D superalloy

Journal of Aeronautical Materials
Residual compressive stress is a critical factor affecting the performance and service life of components. The active introduction and precise control of residual compressive stress have become one of the core technical approaches to improve component ...
LUO Jianxin, ZHANG Wei, LEI Liming, TAN Liang, YAO Changfeng   +4 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source