Results 91 to 100 of about 12,557,310 (317)

Reduce wear and control friction for copper-based powder metallurgy wet friction material by optimizing porosity, surface roughness and surface texture

Alexandria Engineering Journal
Copper-based powder metallurgy materials are common friction materials in many fields such as aviation, high-speed railway and automobiles because of their good thermal conductivity, stable friction performance and relatively high mechanical properties ...
Zhi Chen, Yuedu Chen, Wuzhong Tang, Zhizhong Zhang, Weihai Xue, Huiming Guo, Fenglin Han   +6 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Mechanism of heterogeneous substrate stimulating growth for nickel-based single crystal superalloy

Journal of Materials Research and Technology
Minimizing the deviation of single-crystal (SX) primary orientation can significantly enhance the yield rate, service life, and performance of turbine blades or castings.
Binqiang Wang, Senhong Chen, Long Zeng, Mingxu Xia, Jianguo Li, Kun Bu   +5 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Performance and carbon emissions of a diesel/oxy-hydrogen dual-fuel engine with oxy-hydrogen injection variation under low and medium load conditions

International Journal of Renewable Energy Development
Reducing carbon emissions such as carbon dioxide (CO2) and carbon monoxide (CO) from diesel engines struggled with engine performance challenges and fossil fuel limitations. Besides, huge transportation such as ships hardly replaced diesel engines due to
Frengki Mohamad Felayati, Hadi Prasutiyon, Sholikhatul Janah, Dimas Hadi Wijaya, Mukhammat Bayu Saputra, Semin Semin   +5 more
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Modeling of Geometric Parameters⁃Components‑Overall Performance in Turboshaft Engines and Their Applications

Nanjing Hangkong Hangtian Daxue Xuebao
Aiming at the problem of performance dispersion of domestic turboshaft engines in batch production， a model-building method integrating manufacturing geometric parameters， component performance， and overall engine performance is proposed.
LI Zeqi, XI Long, DENG Haomin, ZHOU Wenxiang, SUN Siqi   +4 more
doaj   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source