Results 91 to 100 of about 930,385 (313)

Engineering the Performance [PDF]

Social Studies of Science, 2004
At the dawn of sound recording, recordists were mechanical engineers whose only training was on the job. As the recording industry grew more sophisticated, so did the technology used to make records, yet the need for recording engineers to use craft skill and tacit knowledge in their work did not diminish.
openaire   +1 more source

Analysis of a topping-cycle, aircraft, gas-turbine-engine system which uses cryogenic fuel [PDF]

A topping-cycle aircraft engine system which uses a cryogenic fuel was investigated. This system consists of a main turboshaft engine that is mechanically coupled (by cross-shafting) to a topping loop, which augments the shaft power output of the system.
Fishbach, L. H., Turney, G. E.
core   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Molecular cancer prevention: Intercepting disease

Molecular Oncology, EarlyView.
Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco, Tej Pandya, Charles Swanton   +2 more
wiley   +1 more source

Performance and surge limits of a TF30-P-3 turbofan engine/axisymmetric mixed-compression inlet propulsion system at Mach 2.5 [PDF]

Steady-state performance and inlet-engine compatibility were investigated with a low-bleed inlet. The inlet had minimum internal contraction, consistent with high total pressure recovery and low cowl drag.
Neumann, H. E., Shaw, R. J., Wasserbauer, J. F.   +2 more
core   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Study of LH2-fueled topping cycle engine for aircraft propulsion [PDF]

An analytical investigation was made of a topping cycle aircraft engine system which uses a cryogenic fuel. This system consists of a main turboshaft engine which is mechanically coupled (by cross-shafting) to a topping loop which augments the shaft ...
Fishbach, L. H., Turney, G. E.
core   +1 more source

HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein

FEBS Open Bio, EarlyView.
Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley   +1 more source

Integrated Explainable Diagnosis of Gear Wear Faults Based on Dynamic Modeling and Data-Driven Representation

Sensors
Gear wear degrades transmission performance, necessitating highly reliable fault diagnosis methods. To address the limitations of existing approaches—where dynamic models rely heavily on prior knowledge, while data-driven methods lack interpretability ...
Zemin Zhao, Tianci Zhang, Kang Xu, Jinyuan Tang, Yudian Yang   +4 more
doaj   +1 more source

A Probabilistic Design Methodology for a Turboshaft Engine Overall Performance Analysis

Advances in Mechanical Engineering, 2014
In reality, the cumulative effect of the many uncertainties in engine component performance may stack up to affect the engine overall performance. This paper aims to quantify the impact of uncertainty in engine component performance on the overall ...
Min Chen, Kun Zhang, Hai-Long Tang
doaj   +1 more source