Results 131 to 140 of about 82,857 (303)

Engineered cardiac tissue model of restrictive cardiomyopathy for drug discovery. [PDF]

Cell Rep Med, 2023
Wang BZ, Nash TR, Zhang X, Rao J, Abriola L, Kim Y, Zakharov S, Kim M, Luo LJ, Morsink M, Liu B, Lock RI, Fleischer S, Tamargo MA, Bohnen M, Welch CL, Chung WK, Marx SO, Surovtseva YV, Vunjak-Novakovic G, Fine BM.   +20 more
europepmc   +1 more source

Preliminary Study of a Ninj1‐Loaded Bimodal Ultrasound/NIR Fluorescence Targeted Molecular Probe for Diagnosing Early‐Stage Inflammation in Coronary Microvascular Dysfunction

Advanced Healthcare Materials, EarlyView.
Coronary microvascular dysfunction (CMD) targeting remains a challenge for precise diagnosis. This work presents a dual‐modal nanoprobe (T‐IR780‐NBs) that combines ultrasound contrast with near‐infrared fluorescence. This technology utilizes proteomics‐derived antibodies that specifically localize to inflamed and injured cardiac tissue, enabling ...
Xiaohui Xu, Lina Guan, Baihetiya Tayier, Chen Yuan, Shangke Chen, Qi Shi, Yuming Mu   +6 more
wiley   +1 more source

3D bioprinted aged human post‐infarct myocardium tissue model

Health Science Reports
Background and Aims Fibrotic tissue formed after myocardial infarction (MI) can be as detrimental as MI itself. However, current in vitro cardiac fibrosis models fail to recapitulate the complexities of post‐MI tissue.
Gozde Basara, Lara Ece Celebi, George Ronan, Victoria Discua Santos, Pinar Zorlutuna   +4 more
doaj   +1 more source

ERRγ agonist under mechanical stretching manifests hypertrophic cardiomyopathy phenotypes of engineered cardiac tissue through maturation. [PDF]

Stem Cell Reports, 2023
Fujiwara Y, Miki K, Deguchi K, Naka Y, Sasaki M, Sakoda A, Narita M, Imaichi S, Sugo T, Funakoshi S, Nishimoto T, Imahashi K, Yoshida Y.   +12 more
europepmc   +1 more source

Infusible Extracellular Matrix Biomaterial Enhances Cell‐Specific Pro‐Repair Responses Following Acute Myocardial Infarction

Advanced Healthcare Materials, EarlyView.
We measure the cell‐specific responses of administering infusible ECM (iECM) in acute myocardial infarction (MI) across multiple timepoints. Using single‐nucleus RNA sequencing and spatial transcriptomics, we measure macrophage activation, fibroblast remodeling, increased vascular development, lymphangiogenesis, cardioprotection, and neurogenesis ...
Joshua M. Mesfin, Alexander Chen, Quincy P. Lyons, Michael B. Nguyen, Maria L. Karkanitsa, Justin Yu, Van K. Ninh, Emily Gardner, Elyse G. Wong, Sriya N. Paleti, Julian Cheng, Benjamin D. Bridgelal, Kate E. Reimold, Selena Cao, Connor Uhre, Colin G. Luo, Zhenxing Fu, Kevin R. King, Karen L. Christman   +18 more
wiley   +1 more source

Biomimetic Polymers for Cardiac Tissue Engineering

Biomacromolecules, 2016
Heart failure is a morbid disorder characterized by progressive cardiomyocyte (CM) dysfunction and death. Interest in cell-based therapies is growing, but sustainability of injected CMs remains a challenge. To mitigate this, we developed an injectable biomimetic Reverse Thermal Gel (RTG) specifically engineered to support long-term CM survival.
Peña, Brisa, Martinelli, Valentina, Jeong, Mark, Bosi, Susanna, Lapasin, Romano, Taylor, Matthew RG, Long, Carlin S, Shandas, Robin, Park, Daewon, Mestroni, Luisa   +9 more
openaire   +4 more sources

Generation of bioartificial hearts using decellularized scaffolds and mixed cells

BioMedical Engineering OnLine, 2019
Background Patients with end-stage heart failure must receive treatment to recover cardiac function, and the current primary therapy, heart transplantation, is plagued by the limited supply of donor hearts.
Cailing Tong, Cheng Li, Baiyi Xie, Minghui Li, Xianguo Li, Zhongquan Qi, Junjie Xia   +6 more
doaj   +1 more source

Contractile deficits in engineered cardiac microtissues as a result of MYBPC3 deficiency and mechanical overload. [PDF]

, 2018
The integration of in vitro cardiac tissue models, human induced pluripotent stem cells (hiPSCs) and genome-editing tools allows for the enhanced interrogation of physiological phenotypes and recapitulation of disease pathologies.
Boggess, Steven, Conklin, Bruce R, Grigoropoulos, Costas P, Healy, Kevin E, Huebsch, Nathaniel, Koo, Sangmo, Ma, Zhen, Mandegar, Mohammad A, Siemons, Brian   +8 more
core   +1 more source

Antimicrobial Efficacy of a Taurolidine‐Based Antimicrobial Compound on Contaminated Surfaces Simulated in a Standardized 4‐Field Test

Advanced Healthcare Materials, EarlyView.
As implantable medical devices become indispensable to modern medicine, a silent threat grows alongside them: device‐associated infections. Despite decades of antibiotic innovation, infection rates keep climbing, costing lives and billions in healthcare expenses.
Benito Baldauf, Hendrik Bonnemeier, Ernest W. Lau, Jana Hummel, Reinhard Vonthein, Ojan Assadian   +5 more
wiley   +1 more source

Integrative approaches in cardiac tissue engineering: Bridging cellular complexity to create accurate physiological models

iScience
Summary: Recent innovations in cardiac tissue engineering (TE) have yet to fully harness integrative genomic mapping of cellular niches to replicate the spatially organized cellular communities and extracellular matrix (ECM) microniches of the heart ...
Dilip Thomas, Joseph C. Wu
doaj   +1 more source