Results 131 to 140 of about 82,815 (304)

Infusible Extracellular Matrix Biomaterial Enhances Cell‐Specific Pro‐Repair Responses Following Acute Myocardial Infarction

Advanced Healthcare Materials, EarlyView.
We measure the cell‐specific responses of administering infusible ECM (iECM) in acute myocardial infarction (MI) across multiple timepoints. Using single‐nucleus RNA sequencing and spatial transcriptomics, we measure macrophage activation, fibroblast remodeling, increased vascular development, lymphangiogenesis, cardioprotection, and neurogenesis ...
Joshua M. Mesfin, Alexander Chen, Quincy P. Lyons, Michael B. Nguyen, Maria L. Karkanitsa, Justin Yu, Van K. Ninh, Emily Gardner, Elyse G. Wong, Sriya N. Paleti, Julian Cheng, Benjamin D. Bridgelal, Kate E. Reimold, Selena Cao, Connor Uhre, Colin G. Luo, Zhenxing Fu, Kevin R. King, Karen L. Christman   +18 more
wiley   +1 more source

Engineered cardiac tissue model of restrictive cardiomyopathy for drug discovery. [PDF]

Cell Rep Med, 2023
Wang BZ, Nash TR, Zhang X, Rao J, Abriola L, Kim Y, Zakharov S, Kim M, Luo LJ, Morsink M, Liu B, Lock RI, Fleischer S, Tamargo MA, Bohnen M, Welch CL, Chung WK, Marx SO, Surovtseva YV, Vunjak-Novakovic G, Fine BM.   +20 more
europepmc   +1 more source

Effects of Uniaxial Cyclic Strain on Endothelial Progenitor Cells [PDF]

, 2017
Despite the high prevalence of calcific aortic valve disease (CAVD), the underlying mechanisms of pathogenesis have not been found yet. Therefore, it is extremely important to study CAVD and understand how it develops.
Zeballos Castro, Maria Alejandra
core   +2 more sources

Decellularized Extracellular Matrix (dECM) in Tendon Regeneration: A Comprehensive Review

Advanced Healthcare Materials, EarlyView.
Decellularized Extracellular Matrix (dECM) offers a promising solution by replicating the native tendon microenvironment and promoting regeneration. This review highlights advances in the decellularization methods, as well as their integration with emerging technologies and translational progress in tendon tissue engineering.
Kumaresan Sakthiabirami, Yeonwoo Park, Seong Kyeong Jo, Min Hee Kim, Jae Hwang Song   +4 more
wiley   +1 more source

3D bioprinted aged human post‐infarct myocardium tissue model

Health Science Reports
Background and Aims Fibrotic tissue formed after myocardial infarction (MI) can be as detrimental as MI itself. However, current in vitro cardiac fibrosis models fail to recapitulate the complexities of post‐MI tissue.
Gozde Basara, Lara Ece Celebi, George Ronan, Victoria Discua Santos, Pinar Zorlutuna   +4 more
doaj   +1 more source

ERRγ agonist under mechanical stretching manifests hypertrophic cardiomyopathy phenotypes of engineered cardiac tissue through maturation. [PDF]

Stem Cell Reports, 2023
Fujiwara Y, Miki K, Deguchi K, Naka Y, Sasaki M, Sakoda A, Narita M, Imaichi S, Sugo T, Funakoshi S, Nishimoto T, Imahashi K, Yoshida Y.   +12 more
europepmc   +1 more source

Biomimetic Polymers for Cardiac Tissue Engineering

Biomacromolecules, 2016
Heart failure is a morbid disorder characterized by progressive cardiomyocyte (CM) dysfunction and death. Interest in cell-based therapies is growing, but sustainability of injected CMs remains a challenge. To mitigate this, we developed an injectable biomimetic Reverse Thermal Gel (RTG) specifically engineered to support long-term CM survival.
Peña, Brisa, Martinelli, Valentina, Jeong, Mark, Bosi, Susanna, Lapasin, Romano, Taylor, Matthew RG, Long, Carlin S, Shandas, Robin, Park, Daewon, Mestroni, Luisa   +9 more
openaire   +4 more sources

Targeting the ARRDC3–DRP1 Axis via hUMSC‐Derived Exosomal CRYAB for Neuroprotection in Cerebral Ischemia/Reperfusion Injury

Advanced Healthcare Materials, EarlyView.
Intranasally administered hUMSC‐derived exosomes modulate the CRYAB–ARRDC3–Drp1 axis, alleviating mitochondrial dysfunction and ferroptosis, enhancing neuronal survival, reducing oxidative stress, and promoting functional recovery in ischemia‐reperfusion injury, offering a promising therapeutic strategy for ischemic stroke.
Rong ji, Zengyu Zhang, Zhuohang Liu, Kaicheng Yang, Xueyu Mao, Min Chu, Yong Wang, Jing Zhao   +7 more
wiley   +1 more source

Generation of bioartificial hearts using decellularized scaffolds and mixed cells

BioMedical Engineering OnLine, 2019
Background Patients with end-stage heart failure must receive treatment to recover cardiac function, and the current primary therapy, heart transplantation, is plagued by the limited supply of donor hearts.
Cailing Tong, Cheng Li, Baiyi Xie, Minghui Li, Xianguo Li, Zhongquan Qi, Junjie Xia   +6 more
doaj   +1 more source

Acute Response of Engineered Cardiac Tissue to Pressure and Stretch. [PDF]

Cells Tissues Organs, 2023
Donoghue L, Graham C, Sethu P.
europepmc   +1 more source