Results 51 to 60 of about 1,238,092 (290)
Biomedical Informatics Applications for Precision Management of Neurodegenerative Diseases [PDF]
, 2018 Modern medicine is in the midst of a revolution driven by “big data,” rapidly advancing computing power, and broader integration of technology into healthcare. Highly detailed and individualized profiles of both health and disease states are now possible,
Jimenez-Maggoria, Gustavo +3 more
core +2 more sources
Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
FEBS Letters, EarlyView.The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
The Application of Web-Based Scientific Computing System in Innovation and Entrepreneurship
Discrete Dynamics in Nature and Society, 2022 In the past ten years, the number of newly added labor forces in China has continued to grow. At the same time, with the increase in the number of university candidates, the number of university employments is also increasing.
Tingli Cheng
doaj +1 more source
Game Changing Computational Engineering Technology [PDF]
, 2011 During the last two decades, giant strides have been achieved in many aspects of Computational Engineering. Higher-fidelity mathematical models, better approximation methods, and faster algorithms have been developed for many time-dependent applications. SIMD, SPMD, MIMD, coarse-grain, and fine-grain parallel processors have come and gone.
openaire +1 more source
Cellular Gate Technology [PDF]
, 1997 We propose a biochemically plausible mechanism for constructing digital logic signals and gates of significant complexity within living cells. These mechanisms rely largely on co-opting existing biochemical machinery and binding proteins found naturally ...
Knight, Thomas F., Sussman, Gerald Jay
core +7 more sources
Modelling is for reasoning [PDF]
, 2007 In a broad sense, computing is an area of knowledge from which a popular and effective technology emerged long before a solid, specific, scientific methodology, let alone formal foundations, had been put forward. This might explain some of the weaknesses
Abrial +16 more
core +1 more source
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
Development of a distributed knowledge-based system [PDF]
, 2001 This paper describes the development of a distributed knowledge-based system. A software system, namely Distributed Algorithmic and Rule-based Blackboard System (DARBS), was developed from its predecessor ARBS, which lacked the distributed computing ...
Hopgood, AA, Nolle, L, Wong, KCP
core
FEBS Letters, EarlyView.Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley +1 more source