Results 61 to 70 of about 1,247,044 (291)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Development of a distributed knowledge-based system [PDF]
, 2001 This paper describes the development of a distributed knowledge-based system. A software system, namely Distributed Algorithmic and Rule-based Blackboard System (DARBS), was developed from its predecessor ARBS, which lacked the distributed computing ...
Hopgood, AA, Nolle, L, Wong, KCP
core
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
The Application of Web-Based Scientific Computing System in Innovation and Entrepreneurship
Discrete Dynamics in Nature and Society, 2022 In the past ten years, the number of newly added labor forces in China has continued to grow. At the same time, with the increase in the number of university candidates, the number of university employments is also increasing.
Tingli Cheng
doaj +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
REQUIREMENTS ENGINEERING FOR CLOUD COMPUTING ADAPTIVE MODEL
Journal of ICT, 2016 The easy access and flexibility provided by cloud computing have made various types of organizations use this technology as an alternative solution. However, the decision to use the cloud technology sometimes ignores the basic aspects related to the ...
Kridanto Surendro +2 more
doaj
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
SCRAM: Software configuration and management for the LHC Computing Grid project
, 2003 Recently SCRAM (Software Configuration And Management) has been adopted by the applications area of the LHC computing grid project as baseline configuration management and build support infrastructure tool.
Ashby, S., Wellisch, J. P., Williams, C.
core
AAA+ protein unfoldases—the Moirai of the proteome
FEBS Letters, EarlyView.AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source