Results 61 to 70 of about 146,442 (263)

A multiple-data-based efficient global optimization algorithm and its parallel implementation for automotive body design

open access: yesAdvances in Mechanical Engineering, 2018
The purpose of this article is to improve the convergence efficiency of the traditional efficient global optimization method. Furthermore, we try a graphics processing unit–based parallel computing method to improve the computing efficiency of the ...
Bing Xu, Yong Cai
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

open access: yesFEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

A hierarchy model on the research fields of cyberspace security technology

open access: yes网络与信息安全学报, 2015
Cyberspace security is an interdisciplinary subject involved with computer science and technology,in-formation and communication engineering,control science and engineering and cryptography.It has an explicit and in-depth discipline connotation.First,the
Bin-xing FANG
doaj   +3 more sources

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

open access: yesMolecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce   +11 more
wiley   +1 more source

Integrating Web Technologies with Augmented Reality

open access: yesInternational Journal of Research and Applied Technology
This study aims to provide a comprehensive review of the integration between web technologies and augmented reality (AR) in engineering and computing contexts.
Agis Abhi Rafdhi
doaj   +1 more source

Explaining the AMST Model: Using Arts, Maths, Science, and Technology in an Upgraded Problem-Based Learning Approach [PDF]

open access: yesJournal of Systemics, Cybernetics and Informatics, 2017
Recent literature has touted the importance of the Science, Technology, Engineering, and Mathematics (STEM) curriculum model as the best way to develop a problem-based inquiry in the technology-rich, globally-connected 21st century learning environment ...
Georgia Daleure
doaj  

Big Data and cloud computing: innovation opportunities and challenges

open access: yesInternational Journal of Digital Earth, 2017
Big Data has emerged in the past few years as a new paradigm providing abundant data and opportunities to improve and/or enable research and decision-support applications with unprecedented value for digital earth applications including business ...
Chaowei Yang   +4 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

open access: yesMolecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano   +6 more
wiley   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

The status of MATLAB in the Software Development Market [PDF]

open access: yesITM Web of Conferences
With the continuous development of technology, it is necessary to analyze the applicability of MATLAB in the field of software development according to the mainstream trend of the market.
Wang Pin
doaj   +1 more source

Home - About - Disclaimer - Privacy