Results 51 to 60 of about 1,247,044 (291)

Perspective on big data system computing technology

open access: yes大数据, 2018
The state of the art of big data system computing technology was elaborated and the big data system computing innovation platform at the National Engineering Laboratory for Big Data System Computing Technology was introduced.The platform strives to ...
Haitao WANG, Rui MAO, Zhong MING
doaj  

Machine code and metaphysics : a perspective on software engineering [PDF]

open access: yes, 2014
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly citedA major, but too-little-considered
Cheney   +6 more
core   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Enabling Cloud-based Computational Fluid Dynamics with a Platform-as-a-Service Solution [PDF]

open access: yes, 2018
Computational Fluid Dynamics (CFD) is widely used in manufacturing and engineering from product design to testing. CFD requires intensive computational power and typically needs high performance computing to reduce potentially long experimentation times.
Anagnostou, A.   +15 more
core   +3 more sources

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Game Changing Computational Engineering Technology [PDF]

open access: yes, 2011
During the last two decades, giant strides have been achieved in many aspects of Computational Engineering. Higher-fidelity mathematical models, better approximation methods, and faster algorithms have been developed for many time-dependent applications. SIMD, SPMD, MIMD, coarse-grain, and fine-grain parallel processors have come and gone.
openaire   +1 more source

Evaluating Asymmetric Multicore Systems-on-Chip using Iso-Metrics [PDF]

open access: yes, 2015
The end of Dennard scaling has pushed power consumption into a first order concern for current systems, on par with performance. As a result, near-threshold voltage computing (NTVC) has been proposed as a potential means to tackle the limited cooling ...
Chalios, Charalampos   +2 more
core   +1 more source

The Engineering of a Scalable Multi-Site Communications System Utilizing Quantum Key Distribution (QKD)

open access: yes, 2017
Quantum Key Distribution (QKD) is a means of generating keys between a pair of computing hosts that is theoretically secure against cryptanalysis, even by a quantum computer. Although there is much active research into improving the QKD technology itself,
Ling, Xinhua   +3 more
core   +1 more source

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Cellular Gate Technology [PDF]

open access: yes, 1997
We propose a biochemically plausible mechanism for constructing digital logic signals and gates of significant complexity within living cells. These mechanisms rely largely on co-opting existing biochemical machinery and binding proteins found naturally ...
Knight, Thomas F., Sussman, Gerald Jay
core   +7 more sources

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