Results 51 to 60 of about 146,442 (263)

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Unequal Pathways: Family Background and Youth Computing Aspirations

Socius
Young children are generally enthusiastic about digital technology, yet participation in early computer science pathways remains unequal. Because U.S. children often learn computing outside of school, field-specific knowledge within families may play a ...
Jennifer M. Ashlock, Zeynep Tufekci
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Advanced Brain‐on‐a‐Chip for Wetware Computing: A Review

Advanced Science
In pursuit of low‐power consumption and surpassing computational limitations of silicon‐based chips, people are beginning to seek more efficient computing devices, such as Wetware Computing.
Shangchen Li, Yaoyao Liu, Sihan Hua, Yu Wang, Shutong Sun, Longhui Jiang, Chengji Lu, Juntao Liu, Huaizhang Shi, Pei Wu, Xinxia Cai, Jinping Luo   +11 more
doaj   +1 more source

Collaborative Engineering of Inter-Enterprise Business Processes [PDF]

Journal of Systemics, Cybernetics and Informatics, 2011
Enterprise 2.0 and cloud computing are two of the last years most popular topics. Researchers and Business Analysts see great opportunities and potential for a kind of business application revolution.
Gunter Teichmann, Eva-Maria Schwartz, Frank-Michael Dittes   +2 more
doaj  

Application Research of the Parallel System Theory and the Data Engine Approach in Wind Energy Conversion System

Energies, 2019
The parallel system is a kind of scientific research method based on an artificial system and computational experiments, which can not only reflect the dynamic process of the real system but also optimize its control process in real time. Given the rapid
Zhicheng Lin, Song Zheng, Zhicheng Chen, Rong Zheng, Wang Zhang   +4 more
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Design and Realization of Brake System in Heavy Engineering Vehicle based on Web Theory

Jixie chuandong, 2015
In order to solve the problems of the design and simulation analysis software portability and interoperability deficiencies of existing heavy engineering vehicle brake system,by using the Browser/Server and Client/Server hybrid structure,combined the JSP.
Ma Zhanbao, Wang Jing
doaj  

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Meaning and Vision of Mimic Computing and Mimic Security Defense

Dianxin kexue, 2014
To facilitate high-performance and high-security computing, a technology system based on mimic computing（MC）and mimic security defense（MSD）was proposed. The proposed system focused on both the multi-dimensional reconfigurable and functional architecture ...
Jiangxing Wu
doaj   +2 more sources