Results 81 to 90 of about 185,762 (313)

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

A hierarchy model on the research fields of cyberspace security technology

网络与信息安全学报, 2015
Cyberspace security is an interdisciplinary subject involved with computer science and technology,in-formation and communication engineering,control science and engineering and cryptography.It has an explicit and in-depth discipline connotation.First,the
Bin-xing FANG
doaj   +3 more sources

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Meaning and Vision of Mimic Computing and Mimic Security Defense

Dianxin kexue, 2014
To facilitate high-performance and high-security computing, a technology system based on mimic computing（MC）and mimic security defense（MSD）was proposed. The proposed system focused on both the multi-dimensional reconfigurable and functional architecture ...
Jiangxing Wu
doaj   +2 more sources

Explaining the AMST Model: Using Arts, Maths, Science, and Technology in an Upgraded Problem-Based Learning Approach [PDF]

Journal of Systemics, Cybernetics and Informatics, 2017
Recent literature has touted the importance of the Science, Technology, Engineering, and Mathematics (STEM) curriculum model as the best way to develop a problem-based inquiry in the technology-rich, globally-connected 21st century learning environment ...
Georgia Daleure
doaj  

Big Data and cloud computing: innovation opportunities and challenges

International Journal of Digital Earth, 2017
Big Data has emerged in the past few years as a new paradigm providing abundant data and opportunities to improve and/or enable research and decision-support applications with unprecedented value for digital earth applications including business ...
Chaowei Yang, Qunying Huang, Zhenlong Li, Kai Liu, Fei Hu   +4 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Web-based Collaborative Engineering based on Information Sharing - HydroWeb: An Education Experiment in the Internet [PDF]

, 2004
This paper describes the concept and experiences of the international Open Distance Learning Course ‘HydroWeb’. This course deals with the introduction of Web-based Collaborative Engineering in standard education programmes of water related engineering ...
Molkenthin, Frank
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

The status of MATLAB in the Software Development Market [PDF]

ITM Web of Conferences
With the continuous development of technology, it is necessary to analyze the applicability of MATLAB in the field of software development according to the mainstream trend of the market.
Wang Pin
doaj   +1 more source