Results 91 to 100 of about 6,192,768 (304)

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

open access: yesMolecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck   +12 more
wiley   +1 more source

Emotion, engineering and ethics [PDF]

open access: yes, 2008
Adopting Martha Nussbaum's view provides grounds for recognizing those bursts of anger or delight and the responses to them that alter the course of development of engineering projects.
Monk, John
core  

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

open access: yesMolecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto   +8 more
wiley   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

open access: yesMolecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié   +13 more
wiley   +1 more source

Fast iterative solvers for geomechanics in a commercial FE code [PDF]

open access: yes, 2009
There is a pressing need to improve the feasibility of three-dimensional finite element (FE) methods applied to many problems in civil engineering. This is particularly the case for static analyses in geotechnical engineering: ideally, models would be 3D,
A. Ramage   +4 more
core   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

Engineering Challenges in All-Photonic Quantum Repeaters

open access: yesIEEE Network
9 pages, 4 figures, 2 tables; comments welcome!
Naphan Benchasattabuse   +2 more
openaire   +2 more sources

Science led vs design led teaching approaches in materials science and engineering for aeronautical engineering students [PDF]

open access: yes, 2013
A comparison on teaching styles has been conducted by analysing behavioural, cognitive, developmental, social cognitive and constructivist perspectives of 26 students (higher engineering apprentices).
Inam, Fawad
core  

Next‐generation proteomics improves lung cancer risk prediction

open access: yesMolecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj   +4 more
wiley   +1 more source

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