In this explorative biomarker analysis, we assessed serial sampling of circulating tumor cells (CTCs) with CellSearch in two randomized trials testing immune checkpoint inhibitors (ICIs) in metastatic breast cancer. Our data demonstrate a prognostic potential of CTCs, most apparent 4 weeks into ICI therapy.
Nikolai Kragøe Andresen+13 more
wiley +1 more source
Theorizing neuro-induced relationships between cognitive diversity, motivation, grit and academic performance in multidisciplinary engineering education context [PDF]
Nowadays, engineers need to tackle many unprecedented challenges that are often complex, and, most importantly, cannot be exhaustively compartmentalized into a single engineering discipline. In other words, most engineering problems need to be solved from a multidisciplinary approach. However, conventional engineering programs usually adopt pedagogical
arxiv +1 more source
Design for All as a Challenge for Hypermedia Engineering
JUCS - Journal of Universal Computer Science Volume Nr.
openaire +2 more sources
Circulating tumor cells: advancing personalized therapy in small cell lung cancer patients
Small cell lung cancer (SCLC) is an aggressive form of lung cancer that spreads rapidly to secondary sites such as the brain and liver. Cancer cells circulating in the blood, “circulating tumor cells” (CTCs), have demonstrated prognostic value in SCLC, and evaluating biomarkers on CTCs could guide treatment decisions such as for PARP inhibitors ...
Prajwol Shrestha+6 more
wiley +1 more source
Development of a Practical Synthesis of the 8‑FDC Fragment of OPC-167832
Vijayagopal Gopalsamuthiram+16 more
doaj +1 more source
Optimizing the placement of new wells and well spacing are vital issues in oilfield development. In recent years, the use of particle swarm algorithm (PSA) in many reservoir applications has gained wide acceptance.
Evans Annan Boah+3 more
doaj +1 more source
Evaluating search engines and defining a consensus implementation [PDF]
Different search engines provide different outputs for the same keyword. This may be due to different definitions of relevance, and/or to different knowledge/anticipation of users' preferences, but rankings are also suspected to be biased towards own content, which may prejudicial to other content providers.
arxiv
A comparative study of circulating tumor cell isolation and enumeration technologies in lung cancer
Lung cancer cells were spiked into donor blood to evaluate the recovery rates of the following circulating tumor cell (CTC) enrichment technologies: CellMag™, EasySep™, RosetteSep™, Parsortix® PR1, and Parsortix® Prototype systems. Each method's advantages and disadvantages are described.
Volga M Saini+11 more
wiley +1 more source
Percentage of all students and international students who graduate from sciences and engineering programmes, by tertiary ISCED level (2013) [PDF]
openalex +2 more sources
Cell‐free and extracellular vesicle microRNAs with clinical utility for solid tumors
Cell‐free microRNAs (cfmiRs) are small‐RNA circulating molecules detectable in almost all body biofluids. Innovative technologies have improved the application of cfmiRs to oncology, with a focus on clinical needs for different solid tumors, but with emphasis on diagnosis, prognosis, cancer recurrence, as well as treatment monitoring.
Yoshinori Hayashi+6 more
wiley +1 more source