Results 61 to 70 of about 481,484 (270)
FEBS Letters, EarlyView.Low‐density lipoprotein receptor‐related protein 6 (LRP6) is a key receptor for the Wnt antagonist Dickkopf1 (DKK1). DKK1 protein expression is induced in a bleomycin (BLM)‐induced lung injury model. We show that DKK1 induces proinflammatory and profibrotic genes in lung fibroblasts.
Eun‐Ah Sung +6 more
wiley +1 more source
Software Engineering und Software Engineering Forschung im Zeitalter der Digitalisierung [PDF]
arXiv, 2020 Digitization not only affects society, it also requires a redefinition of the location of computer science and computer scientists, as the science journalist Yogeshwar suggests. Since all official aspects of digitalization are based on software, this article is intended to attempt to redefine the role of software engineering and its research.
arxiv
Characteristics of the Kelch domain containing (KLHDC) subfamily and relationships with diseases
FEBS Letters, EarlyView.The Kelch protein superfamily includes 63 members, with the KLHDC subfamily having 10 proteins. While their functions are not fully understood, recent advances in KLHDC2's structure and role in protein degradation have highlighted its potential for drug development, especially in PROTAC therapies.
Courtney Pilcher +6 more
wiley +1 more source
Insertion of the FeB cofactor in cNORs lacking metal inserting chaperones
FEBS Letters, EarlyView.Nitric oxide reductase is an enzyme found in the bacterial denitrification pathway. The NOR active site contains a non‐heme iron, often, but not always inserted with the assistance of chaperones. Here, we study the insertion of FeB in the subfamily of cNORs lacking chaperones and found a putative channel, conserved in the family, perhaps enabling the ...
Sofia Appelgren, Pia Ädelroth
wiley +1 more source
Journal of Translational Medicine, 2022 Background Early prediction of response to neoadjuvant chemotherapy (NACT) is important to aid personalized treatment in osteosarcoma. Diffusion-weighted Intravoxel Incoherent Motion (IVIM) MRI was used to evaluate the predictive value for response to ...
Esha Baidya Kayal +8 more
doaj +1 more source
"openness of search engine": A critical flaw in search systems; a case study on google, yahoo and bing [PDF]
arXiv, 2012 There is no doubt that Search Engines are playing a great role in Internet usage. But all the top search engines Google, Yahoo and Bing are having a critical flaw called "Openness of a Search Engine". An Internet user should be allowed to get the search results only when requested through Search engine's web page but the user must not be allowed to get
arxiv
Taurine promotes glucagon‐like peptide‐1 secretion in enteroendocrine L cells
FEBS Letters, EarlyView.Taurine, a sulfur‐containing amino acid, is likely taken up by enteroendocrine L cells via the taurine transporter. This process increases the levels of cytosolic ATP. The increase in intracellular Ca2+ concentrations and glucagon‐like peptide‐1 secretion through membrane depolarization is caused by the closure of ATP‐sensitive potassium channels ...
Yuri Osuga +6 more
wiley +1 more source
Top-down Paradigm in Engineering Software Integration [PDF]
arXiv, 2009 The top-down approach of engineering software integration is considered in this parer. A set of advantages of this approach are presented, by examples. All examples are supplied by open source code.
arxiv
FEBS Letters, EarlyView.The NlpC_P60 superfamily of peptidases is recognised by its key role in bacterial cell wall homeostasis. Recently, studies have also described the involvement of NlpC_P60‐like enzymes in bacterial competitive mechanisms and pathogenesis across several lineages.
Catharina dos Santos Silva +1 more
wiley +1 more source
Technique of the X-Parameters Measurements of S-Band Power Amplifier
Известия высших учебных заведений России: Радиоэлектроника, 2016 Performed a series of the X-parameters measurements of high-power S-band power amplifier. This method is the foundation to provide similar measurements and as result to obtain the behavioral model of power amplifier to further simulations in ADS.
O. A. Adonev +5 more
doaj