Results 91 to 100 of about 10,289,638 (297)

Engineering Vanderbilt; Vol. 46 No. 02, 2005

, 2005
Engineering Vanderbilt (formerly Engineering News) is the newsletter of the Vanderbilt University School of EngineeringSchool of ...
Vanderbilt University. School of Engineering
core  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Engineering Vanderbilt; Vol. 43 No. 01, 2002

, 2002
Engineering Vanderbilt (formerly Engineering News) is the newsletter of the Vanderbilt University School of EngineeringSchool of ...
Vanderbilt University. School of Engineering
core  

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Influence of ground-motion selection on the nonlinear response of curved surface slider isolation systems

Frontiers in Built Environment
The paper investigates how different ground-motion selection procedures influence the non-linear seismic response of base-isolated systems, with particular focus on curved surface slider used for safety-relevant structures.
Soumitra Chatterji, Philippe L. A. Renault, Christoph Butenweg, Felix Weber   +3 more
doaj   +1 more source

Engineering Vanderbilt; Vol. 50 No. 02, 2009

, 2009
Engineering Vanderbilt (formerly Engineering News) is the newsletter of the Vanderbilt University School of Engineering.Vanderbilt University.
Vanderbilt University. School of Engineering
core  

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Application method of determining polymer injection timing with relative permeability curves

Youqicang pingjia yu kaifa, 2020
The early polymer injection technology can further improve the polymer flooding effect, and the method to judge the time of polymer transfer by laboratory experiment and numerical simulation is relatively complex and limited in application.
ZHU Shijie, SHI Leiting, ZHANG Jian, LI YanLi, WANG Gang, XUE Xinsheng, YE Zhongbin   +6 more
doaj  

Engineering Vanderbilt; Vol. 46 No. 01, 2005

, 2005
Engineering Vanderbilt (formerly Engineering News) is the newsletter of the Vanderbilt University School of EngineeringSchool of ...
Vanderbilt University. School of Engineering
core  

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source