Results 71 to 80 of about 10,289,638 (297)

An engineering design knowledge reuse methodology using process modelling [PDF]

, 2007
This paper describes an approach for reusing engineering design knowledge. Many previous design knowledge reuse systems focus exclusively on geometrical data, which is often not applicable in early design stages.
Young, Bob, Harding, Jenny, Cochrane, Sean, Dani, Shilpa, Gao, James, Harding, Jennifer, Baxter, David, Young, Robert, Gao, James X., Case, Keith   +9 more
core   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Inventory control in case of unknown demand and control parameters. [PDF]

This thesis deals with unknown demand and control parameters in inventory control. Inventory control involves decisions on what to order when and in what quantity. These decisions are based on information about the demand.
Janssen, E.
core  

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Optimal Seismic Intensity Measure Selection for Isolated Bridges under Pulse-Like Ground Motions

Advances in Civil Engineering, 2019
Isolated bridges are commonly designed in the near-fault region to balance excessive displacement and seismic force. Optimal intensity measures (IMs) of probabilistic seismic demand models for isolated bridges subjected to pulse-like ground motions are ...
Linwei Jiang, Jian Zhong, Min He, Wancheng Yuan   +3 more
doaj   +1 more source

Safety management of deep excavation engineering in subway stations based on soil mechanics response simulation analysis [PDF]

Archives of Civil Engineering
As the economy develops with the continuous acceleration of modern urban construction, the demand for subway construction has been increasing. When constructing subway stations, the safety management of deep foundation pit support engineering is ...
Deqiu Zhang, Jingyan Wang
doaj   +1 more source

How to Determine the Order-up-to Level When Demand is Gamma Distributed with Unknown Parameters [PDF]

Inventory models need information about the demand distribution. In practice, this information is not known with certainty and has to be estimated with often relatively few historical demand observations.
Brekelmans, R.C.M., Strijbosch, L.W.G., Janssen, E.   +2 more
core  

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Quantifying building engineering demand parameters in seismic events [PDF]

, 2012
Engineering demand parameters (EDPs), such as inter-storey drift or floor acceleration, can be correlated to structural, non-structural and content damage within a structure.
Uma, S.R., Dhakal, Rajesh, MacRae, G.A., Yeow, T.Z., Dantanarayan, H.   +4 more
core   +2 more sources

‘Guide and Prejudice’— How Argonautes recognize targets across domains of life

FEBS Letters, EarlyView.
Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley   +1 more source