E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
A memorized multi-objective Sinh-Cosh optimizer for solving multi-objective engineering design problems. [PDF]
Sci RepEl-Nagar D, Zeidan I, Issa M.
europepmc +1 more source
Following values in engineering design and conception practices [PDF]
Mylène Tanferri, Dominique Vinck
openalex +1 more source
Assessing the Impact of Incorporating the NAE Grand Challenges for Engineering as a Multidisciplinary Hands-On Design Project into the Introduction to Engineering Course [PDF]
, 2016 Haolin Zhu, Amy Trowbridge
openalex +1 more source
Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics
FEBS Open Bio, EarlyView.Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini +2 more
wiley +1 more source
An adaptive multi-scale kriging framework with committee-based infill for engineering design optimization. [PDF]
Sci RepXie H, Zhong Q, Zeng W.
europepmc +1 more source
Innovations in Remote Teaching of Engineering Design Teams. [PDF]
Annu Conf Expo (Am Soc Eng Educ), 2023 Kang S +8 more
europepmc +1 more source
Overview of molecular signatures of senescence and associated resources: pros and cons
FEBS Open Bio, EarlyView.Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas +6 more
wiley +1 more source
Correction: An axiomatic system engineering design method based on NSGA-II algorithm applied to complex systems. [PDF]
Sci RepZhang X +7 more
europepmc +1 more source
An Explicit Creep-Fatigue Model for Engineering Design Purposes [PDF]
, 2018 Dan Liu, Dirk Pons
openalex +1 more source