Results 131 to 140 of about 2,391,467 (334)
An investigation into the adoption of CDIO in distance learning [PDF]
, 2008 The Conceive, Design, Implement and Operate Initiative (CDIO) uses integrated learning to develop deep learning of the disciplinary knowledge base whilst simultaneously developing personal, interpersonal, product, process and system building skills. This
Brodie, Lyn +4 more
core
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Sustainable development as a meta-context for engineering education [PDF]
, 2011 At the end of the first decade of the twenty-first century, there is unprecedented awareness of the need for a transformation in development, to meet the needs of the present while also preserving the ability of future generations to meet their own needs.
Desha, Cheryl +2 more
core +1 more source
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Individual sustainability competence development in engineering education: Community interaction open-source learning. [PDF]
PLoS One, 2023 Li H +6 more
europepmc +1 more source
Analysis of international graduate programmes structures for engineering education [PDF]
, 2010 This article traces the evolution of graduate study in Engineering in Ireland over three decades. Very few studies have shown the different norms and structures of graduate programmes in Ireland.
Brabazon, Dermot +3 more
core
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Contextual variation on teachers' conceptions of ICT-enhanced teaching in engineering education. [PDF]
Heliyon, 2023 Khalid M, Hossain Khan MS, Gregory S.
europepmc +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Transdisciplinary experiential learning in biomedical engineering education for healthcare systems improvement. [PDF]
BMC Med Educ, 2023 Montesinos L +2 more
europepmc +1 more source