Results 161 to 170 of about 9,039,452 (379)

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

open access: yesMolecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici   +8 more
wiley   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

open access: yesMolecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert   +13 more
wiley   +1 more source

ENGINEERING EDUCATION FOR A RESILIENT SOCIETY

open access: yesВысшее образование в России, 2016
The article addresses engineering education and its contribution to the development of contemporary resilient society. These issues were discussed at the World Engineering Education Forum WEEF 2015 in September 2015 in Florence.
Vasily G. Ivanov   +2 more
doaj  

Multi‐omic profiling of squamous cell lung cancer identifies metabolites and related genes associated with squamous cell carcinoma

open access: yesMolecular Oncology, EarlyView.
Using multi‐omic characterization, we aimed to identify key regulators specific to squamous cell lung carcinoma (SqCC). SqCC‐specific differentially expressed genes were integrated with metabolics data. High expression of the creatine transporter SLC6A8, along with elevated creatine levels, appeared to be a distinct metabolic feature of SqCC.
Johan Staaf   +10 more
wiley   +1 more source

ENGINEERING EDUCATION IN THE USA

open access: yesВысшее образование в России, 2016
The article examines education of engineering workforce as one of the priority areas for the US education system development, analyzes the structure of undergraduate engineering programs, discusses the quality of engineering education, as well as the ...
Tat’yana B. Mednikova   +1 more
doaj  

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