Results 181 to 190 of about 2,376,720 (336)

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Lactoferrin treatment activates acetylcholinesterase, decreasing acetylcholine levels in non‐small cell lung cancer (NSCLC) cell culture supernatants, inhibiting cell survival

FEBS Open Bio, EarlyView.
Representation of the suggested mode of action of lactoferrin (Lf) in nonsmall cell lung cancer (NSCLC) A549 cells. Lf induces activation of caspase‐3 by activating p53 and AChE leading to decreased ACh concentrations. In turn, ACh signaling leads to activation of VEGF and AKT and blocking of caspase‐3.
Stuti Goel, Caroline Wozniak, Aya Sabri, Ben Haddad, Brooke Lopo, Alvaro Cobos, Sarah Sarofim, Jeffrey Guthrie, Deborah Heyl, Hedeel Guy Evans   +9 more
wiley   +1 more source

A Web-Based Digital Twin Framework for Interactive E-Learning in Engineering Education [PDF]

Peter Weis, Ronald Bašťovanský, Matúš Vereš   +2 more
openalex   +1 more source

Overexpression of CDT1 inhibits cell cycle progression at S phase by interacting with the mini‐chromosome maintenance complex and causes DNA damage

FEBS Open Bio, EarlyView.
CDT1 is an essential protein for DNA replication licensing that loads the MCM complex, the eukaryotic replicative DNA helicase, onto replication origins. Overexpression of CDT1 induces cell cycle arrest at the S phase. Here we showed CDT1 inhibits the progression of replication forks by interacting with the MCM complex, leading to the stalling and ...
Takashi Tsuyama, Nonoka Takayama, Rina Tanaka, Yuuki Arai, Yohko Yamaguchi, Yuko Nawata, Yutaro Azuma, Shusuke Tada   +7 more
wiley   +1 more source

Review of flipped learning in engineering education: Scientific mapping and research horizon. [PDF]

Educ Inf Technol (Dordr), 2022
Al Mamun MA, Azad MAK, Al Mamun MA, Boyle M.   +3 more
europepmc   +1 more source

Teaching Design and New Engineering Education Practice for the Interdisciplinary Course "Energy Storage Technologies for Smart Grids" [PDF]

openalex   +1 more source

A general model for analysis of linear and hyperbolic enzyme inhibition mechanisms

FEBS Open Bio, EarlyView.
We developed a general enzyme kinetic model that integrates these six basic inhibition mechanism onto a single one. From this model, we deduced a general enzyme kinetic equation that through modulation of simple parameters, γ (the relative inhibitor affinity for two binding sites) and β (the reactivity of the enzyme–substrate–inhibitor complex), is ...
Rafael S. Chagas, Sandro R. Marana
wiley   +1 more source

The Adaptive Lab Mentor (ALM): An AI-Driven IoT Framework for Real-Time Personalized Guidance in Hands-On Engineering Education. [PDF]

Sensors (Basel)
Hasan MS, Ahmed A, Rasool N, Jabe MMN, Zeng X, Ali Pirzado F.   +5 more
europepmc   +1 more source

Biomedical Engineering Education and the Special COVID-19 Issue. [PDF]

Biomed Eng Educ, 2021
Saterbak A, Huang-Saad A, P Helmke B.
europepmc   +1 more source

Spine International Benchmarking Of Successful Practices In Engineering Education [PDF]

, 2020
John F. Anderson, Jean‐Lou Chameau, Dick K. P. Yue   +2 more
openalex   +1 more source