Results 51 to 60 of about 2,391,467 (334)

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

open access: yesFEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

open access: yesFEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang   +9 more
wiley   +1 more source

A framework for design engineering education in a global context [PDF]

open access: yes, 2010
This paper presents a framework for teaching design engineering in a global context using innovative technologies to enable distributed teams to work together effectively across international and cultural boundaries.
Ade Mabogunje   +13 more
core   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

open access: yesFEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira   +3 more
wiley   +1 more source

Reframing neurodiversity in engineering education

open access: yesFrontiers in Education, 2022
A growing body of literature suggests that neurodiverse learners may possess assets that are highly desirable within engineering disciplines. Even so, despite the potential of neurodiverse individuals to contribute to innovation in science and ...
Maria Chrysochoou   +2 more
doaj   +1 more source

Creativity in Mass-Education Contexts [PDF]

open access: yes, 2006
This paper discusses a learning framework (working title: ‘fog framework’) that has been developed in response to the challenge of teaching creative subjects in a mass-education context.
Anusas, M.
core  

Technical and vocational education in Malaysia: policy, leadership, and professional growth on Malaysia women [PDF]

open access: yes, 2015
Technical and Vocational Education (TVE) is facing new challenges in an increasingly competitive global context. The continuing under representation of women in engineering fields at semi-skilled and high-skilled levels is receiving renewed attention ...
Lai, Chee Sern   +3 more
core   +1 more source

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

open access: yesFEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom   +3 more
wiley   +1 more source

Technological Education and Engineering Pedagogy

open access: yesОбразование и наука, 2020
Introduction. Technological education, being a part of the school curriculum, is presented as a factor and a means of students’ socialisation and as “a process and a result of active learning by schoolchildren the general and professional technological ...
D. P. Danilaev, N. N. Malivanov
doaj   +1 more source

Nuclear engineering program marks 10th anniversary [PDF]

open access: yes, 2017
Ten years ago, Virginians who wanted to study nuclear engineering at the graduate level had to leave the state to do so. But then VCU, with support from Dominion Resources, started a program whose hallmark has been its ability to balance theory and ...
Jones, Rebecca
core   +1 more source

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