Results 81 to 90 of about 2,373,501 (286)
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Managing the complexities of English Language teaching in engineering [PDF]
, 2015 In this 21st century, engineering employers seek professional engineers who have excellent scientific knowledge and are able to demonstrate good communication and problem solving skills.
Mohamed, Mimi Nahariah Azwani
core +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Global movement for engineering education accreditation
آموزش مهندسی ایران, 2011 Engineering is an international activity, thus engineering education should be considered as an international affair as well. From the beginning of the present century, progression of engineers outside their own country, study of higher education or ...
Hossen Memarian
doaj +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Education, Entrepreneurship and Immigration: America's New Immigrant Entrepreneurs, Part II [PDF]
, 2007 Analyzes the educational backgrounds and career trajectories of immigrant entrepreneurs, finding that advanced education in science, technology, engineering, and mathematics is correlated with high rates of entrepreneurship and ...
AnnaLee Saxenian +3 more
core +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Redefining engineering education: the reflective practice of product design engineering [PDF]
, 2001 The University of Glasgow and the School of Design at the Glasgow School of Art have joined forces to redefine the nature of an engineering curriculum and produce a degree program that is rich in both creative design culture and design engineering skills.
Green, G.
core
Production and Manufacturing Research: An Open Access JournalThe holistic integration of the human workforce in digital and sustainable manufacturing and logistics systems requires structured approaches for the systematic (re-)alignment of professional education initiatives.
Corina Pacher +3 more
doaj +1 more source