Results 201 to 210 of about 3,330,587 (398)

Comparative single‐cell transcriptomic profiling of patient‐derived renal carcinoma cells in cellular and animal models of kidney cancer

open access: yesFEBS Open Bio, EarlyView.
We generated and characterized clear cell renal cell carcinoma models using the patient‐derived RCC243 cell line—including cell culture, orthotopic, and metastatic tumors—via single‐cell RNA‐sequencing for comparisons between models and patient tumor datasets.
Richard Huang   +9 more
wiley   +1 more source

ETHICS OF ENGINEERS: CHALLENGES OF COMPETENCY FORMATION AND ASSESSMENT

open access: yesВысшее образование в России, 2016
The paper covers issues of ethical education for engineering students in Russian universities. The topical character of these issues is grounded by the findings of the survey of self-study reports on degree engineering programs, presented within ...
Yulia V. Gasheva
doaj  

Ethical software requirements from user reviews: A systematic literature review [PDF]

open access: yesarXiv
Context: The growing focus on ethics within SE, primarily due to the significant reliance of individuals' lives on software and the consequential social and ethical considerations that impact both people and society has brought focus on ethical software requirements identification and elicitation.
arxiv  

METTL3 knockout accelerates hepatocarcinogenesis via inhibiting endoplasmic reticulum stress response

open access: yesFEBS Open Bio, EarlyView.
Liver‐specific knockout of N6‐methyladenosine (m6A) methyltransferase METTL3 significantly accelerated hepatic tumor initiation under various oncogenic challenges, contrary to the previously reported oncogenic role of METTL3 in liver cancer cell lines or xenograft models. Mechanistically, METTL3 deficiency reduced m6A deposition on Manf transcripts and
Bo Cui   +15 more
wiley   +1 more source

Soman induces endoplasmic reticulum stress and apoptosis of cerebral organoids via the GRP78‐ATF6‐CHOP signaling pathway

open access: yesFEBS Open Bio, EarlyView.
Cerebral organoids were employed as a novel model to explore the neurotoxicity of soman. Soman inhibited acetylcholinesterase activity, increased cell apoptosis and upregulated endoplasmic reticulum (ER) stress markers glucose‐regulated protein 78 (GRP78), activating transcription factor 6 (ATF6) and C/EBP homologous protein (CHOP).
Yue Wei   +7 more
wiley   +1 more source

Using a Phenomenological Approach to Teach Engineering Ethics in a First-year Engineering Course [PDF]

open access: bronze, 2015
Amy Hamlin   +5 more
openalex   +1 more source

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