Results 131 to 140 of about 4,743,133 (351)

An analysis of final year student project performance in mechanical engineering [PDF]

open access: yes, 2008
This paper describes a statistical analysis of the students' results in mechanical engineering Final Year Project (FYP) at undergraduate level eight. Project marks of the final year students obtained over the past six years (2002-2008) were recorded and ...
Brabazon, Dermot   +3 more
core  

GEO: Generative Engine Optimization

open access: yesProceedings of the 30th ACM SIGKDD Conference on Knowledge Discovery and Data Mining
The advent of large language models (LLMs) has ushered in a new paradigm of search engines that use generative models to gather and summarize information to answer user queries. This emerging technology, which we formalize under the unified framework of generative engines (GEs), can generate accurate and personalized responses, rapidly replacing ...
Pranjal Aggarwal   +5 more
openaire   +2 more sources

Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma

open access: yesMolecular Oncology, EarlyView.
The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias   +12 more
wiley   +1 more source

Computational simulation for concurrent engineering of aerospace propulsion systems [PDF]

open access: yes
Results are summarized for an investigation to assess the infrastructure available and the technology readiness in order to develop computational simulation methods/software for concurrent engineering.
Chamis, C. C., Singhal, S. N.
core   +1 more source

Institutionalising Ontology-Based Semantic Integration [PDF]

open access: yes, 2007
We address what is still a scarcity of general mathematical foundations for ontology-based semantic integration underlying current knowledge engineering methodologies in decentralised and distributed environments. After recalling the first-order ontology-
Kalfoglou, Yannis, Schorlemmer, Marco
core   +1 more source

BMP antagonist CHRDL2 enhances the cancer stem‐cell phenotype and increases chemotherapy resistance in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley   +1 more source

A General-applications Direct Global Matrix Algorithm for Rapid Seismo-acoustic Wavefield Computations [PDF]

open access: yes
A new matrix method for rapid wave propagation modeling in generalized stratified media, which has recently been applied to numerical simulations in diverse areas of underwater acoustics, solid earth seismology, and nondestructive ultrasonic scattering ...
Schmidt, H., Tango, G. J., Werby, M. F.
core   +1 more source

Generative vs. Non-Generative Models in Engineering Shape Optimization

open access: yesJournal of Marine Science and Engineering
Generative models offer design diversity but tend to be computationally expensive, while non-generative models are computationally cost-effective but produce less diverse and often invalid designs. However, the limitations of non-generative models can be overcome with the introduction of augmented shape signature vectors (SSVs) to represent both ...
Zahid Masood   +4 more
openaire   +4 more sources

Simultaneous inhibition of TRIM24 and TRIM28 sensitises prostate cancer cells to antiandrogen therapy, decreasing VEGF signalling and angiogenesis

open access: yesMolecular Oncology, EarlyView.
TRIM24 and TRIM28 are androgen receptor (AR) coregulators which exhibit increased expression with cancer progression. Both TRIM24 and TRIM28 combine to influence the response of castrate‐resistant prostate cancer (CRPC) cells to AR inhibitors by mediating AR signalling, regulation of MYC and upregulating VEGF to promote angiogenesis. Castrate‐resistant
Damien A. Leach   +8 more
wiley   +1 more source

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