Results 31 to 40 of about 65,077 (259)

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Adsorbents Derived from Plant Sources for Caffeine Removal: Current Research and Future Outlook

Engineering Proceedings
Pharmaceutical wastes, due to their recalcitrant nature, are emerging contaminants in wastewater that have been the focus of researchers and scientists.
Rich Jhon Paul Latiza, Adam Mustafa, Keno Delos Reyes, Kharl Laurence Nebres, Rugi Vicente C. Rubi   +4 more
doaj   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Green Synthesis of Zinc Oxide Nanoparticles Using Lepidium sativum Seed Extract Embedded in Sodium Alginate Matrix for Efficient Slow-Release Biofertilizers

Engineering Proceedings
In this research, we developed a novel slow-release biofertilizer by utilizing an environmentally friendly method to synthesize ZnO-NPs using sodium hydroxide, zinc acetate salt, and Lepidium sativum seed extract.
Yasmina Khane, Zoulikha Hafsi, Fares Fenniche, Djaber Aouf, Marwa Laib, Abdelkrim Gagi, Sofiane Khane   +6 more
doaj   +1 more source

LoRa Radius Coverage Map on Urban and Rural Areas: Case Study of Athens’ Northern Suburbs and Tinos Island, Greece

Engineering Proceedings, 2023
As the use and development of Internet of Things is very popular nowadays, one of the most widespread ways of exchanging data from such arrangements is the use of the LoRa network.
Spyridon Mitropoulos, Vasilios A. Orfanos, Dimitrios Rimpas, Ioannis Christakis   +3 more
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Experimental Comparison of Open Sun and Indirect Convection Solar Drying Methods for Apricots in Uzbekistan

Engineering Proceedings
Solar drying is an environmentally friendly and sustainable approach to preserve agricultural products, particularly in regions with abundant sunlight. In terms of apricot cultivation, the implementation of solar drying methods can significantly impact ...
Sarvar Rejabov, Botir Usmonov, Komil Usmanov, Askar Artikov   +3 more
doaj   +1 more source

Design and Development of a Low-Cost and Compact Real-Time Monitoring Tool for Battery Life Calculation

Engineering Proceedings, 2023
Lithium-ion batteries are utilized everywhere from electronic equipment, smartphones and laptops to electric vehicles; however, certain disadvantages are inherited including high-cost and low-temperature range, caused by high currents.
Dimitrios Rimpas, Vasilios A. Orfanos, Pavlos Chalkiadakis, Ioannis Christakis   +3 more
doaj   +1 more source

A Massive Data Parallel Computational Framework for Petascale/Exascale Hybrid Computer Systems

, 2012
Heterogeneous systems are becoming more common on High Performance Computing (HPC) systems. Even using tools like CUDA and OpenCL it is a non-trivial task to obtain optimal performance on the GPU.
Blazewicz, Marek, Brandt, Steven R., Diener, Peter, Koppelman, David M., Kurowski, Krzysztof, Löffler, Frank, Schnetter, Erik, Tao, Jian   +7 more
core   +1 more source

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

FEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee, Ga Seul Lee, JinHan Kim, Kwang‐Hyun Park, Seong‐Ryung Go, Jeong Hee Moon, Eui‐Jeon Woo   +6 more
wiley   +1 more source