Results 41 to 50 of about 3,131,225 (327)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Developing an Effective System for Engineering Management Education: A Teaching Practice and Evaluation Perspective

Education Sciences
In the field of engineering management, teaching emphasizes the cultivation of applied talents within the context of new engineering disciplines. Evaluating the effectiveness of this cultivation is particularly necessary.
Tengfei Zhao, Jianlin Zhu, Zhiyu Jian, Xian Zhou, Siling Yang, Puwei Zhang   +5 more
doaj   +1 more source

Analysis of Importance of Engineering Survey in Construction Engineering Quality Management [PDF]

E3S Web of Conferences, 2020
Engineering survey is an important technology applied in the quality management of construction engineering. By conducting engineering survey, it can provide necessary data support and measurement methods for the early exploration, mid-term construction,
Liu Liguo, Zhang Caixia
doaj   +1 more source

OntoMaven: Maven-based Ontology Development and Management of Distributed Ontology Repositories [PDF]

, 2013
In collaborative agile ontology development projects support for modular reuse of ontologies from large existing remote repositories, ontology project life cycle management, and transitive dependency management are important needs.
Paschke, Adrian
core  

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Improving Recruitment and Retention: A Management Framework to Utilize DMAIC and Kaizen for Student Support in Engineering Education

Trends in Higher Education
The Clay N. Hixson Student Success Center within the College of Engineering at Tennessee Tech University has undergone a transformative upgrade by integrating the Define, Measure, Analyze, Improve, and Control (DMAIC) framework with select Kaizen ...
Kumar Yelamarthi, Elizabeth Powell, Mazen Hussein   +2 more
doaj   +1 more source

Constrained Scheduling Optimization of Improved LLH Resources for Engineering Management [PDF]

International Journal of Mathematical, Engineering and Management Sciences
To investigate how to maximize the benefits of engineering projects through effective scheduling strategies in the context of limited resources, this study develops a high-level heuristic strategy that leverages deep reinforcement learning algorithms ...
Lijun Liu, Luxia Ouyang
doaj   +1 more source

On Evidence-based Risk Management in Requirements Engineering

, 2017
Background: The sensitivity of Requirements Engineering (RE) to the context makes it difficult to efficiently control problems therein, thus, hampering an effective risk management devoted to allow for early corrective or even preventive measures ...
B Boehm, B Lawrence, BW Boehm, D Damian, D Karolak, D Méndez Fernández, D Méndez Fernández, D Méndez Fernández, D Méndez Fernández, M Felderer, M Kalinowski, R Wieringa, S Pfleeger, T DeMarco, T Gorschek, Y Asnar   +15 more
core   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

An Integrated Entropy–MAIRCA Approach for Multi-Dimensional Strategic Classification of Agricultural Development in East Africa

Mathematics
Agricultural development is vital for East Africa’s economic growth, yet the region faces significant disparities and systemic barriers. A critical problem exists due to the lack of an integrated quantitative framework to systematically comparing ...
Chia-Nan Wang, Duy-Oanh Tran Thi, Nhat-Luong Nhieu, Ming-Hsien Hsueh   +3 more
doaj   +1 more source