Results 61 to 70 of about 3,131,225 (327)

Engineering the Climate: The Ethics of Solar Radiation Management [PDF]

open access: yes, 2017
This important edited collection addresses ethical issues associated with solar radiation management (SRM), a category of climate engineering techniques that would increase the planet’s reflectivity in order to offset some of the impacts of anthropogenic
Svoboda, Toby
core   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

Competency requirements for engineering management undergraduates in the era of intelligent construction

open access: yesJournal of Asian Architecture and Building Engineering
In the era of intelligent construction, engineering management requires diverse abilities that cannot be provided through traditional engineering management education.
Dingli Liu   +4 more
doaj   +1 more source

The Environmental Influencing Factors of the Realization of Engineering Construction Harmony from the Perspective of Ren–Shi–Wu: Evidence from China

open access: yesBuildings
Engineering construction involves many internal factors and external environmental factors, resulting in conflict or uncoordinated problems in engineering management.
Weiwei Zuo, Ning Yan, Qiankun Wang
doaj   +1 more source

Boundary Objects and their Use in Agile Systems Engineering

open access: yes, 2019
Agile methods are increasingly introduced in automotive companies in the attempt to become more efficient and flexible in the system development. The adoption of agile practices influences communication between stakeholders, but also makes companies ...
Knauss, Eric   +3 more
core   +1 more source

The organization and management of the Virtual Astronomical Observatory [PDF]

open access: yes, 2012
The U.S. Virtual Astronomical Observatory (VAO; http://www.us-vao.org/) has been in operation since May 2010. Its goal is to enable new science through efficient integration of distributed multi-wavelength data.
Berriman, G. Bruce   +4 more
core   +2 more sources

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

open access: yesMolecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck   +12 more
wiley   +1 more source

The Research of the Project Proprietor’ s Management Control of Engineering Change

open access: yesSHS Web of Conferences, 2015
The problem of the engineering budgetary estimate surpass engineering cost estimate, engineering budget surpass engineering budgetary estimate, engineering final accounts surpass engineering budget in our country’s present stage of the engineering ...
Pan Yanhua, Chen Yanfan
doaj   +1 more source

Starting a Construction Engineering Program at Marquette University [PDF]

open access: yes, 2013
Marquette University decided to start a Construction Engineering and Management program during the 2007 academic year. An endowed chair, titled the McShane Chair in Construction Engineering and Management, was funded by Jim and Kelly McShane to run the ...
Federle, Mark O.
core   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

open access: yesMolecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié   +13 more
wiley   +1 more source

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