Results 61 to 70 of about 3,128,035 (278)

Integration of Sustainable Development Principles into Engineering Management Practices: Analysing the Impact on Companies’ Efficiency and Competitiveness

open access: yesУправленческие науки
The article examines the challenges and tasks related to integrating sustainable development principles into production and technological, engineering and technical, as well as managerial and economic processes.
V. S. Novitskii
doaj   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

The Environmental Influencing Factors of the Realization of Engineering Construction Harmony from the Perspective of Ren–Shi–Wu: Evidence from China

open access: yesBuildings
Engineering construction involves many internal factors and external environmental factors, resulting in conflict or uncoordinated problems in engineering management.
Weiwei Zuo, Ning Yan, Qiankun Wang
doaj   +1 more source

Starting a Construction Engineering Program at Marquette University [PDF]

open access: yes, 2013
Marquette University decided to start a Construction Engineering and Management program during the 2007 academic year. An endowed chair, titled the McShane Chair in Construction Engineering and Management, was funded by Jim and Kelly McShane to run the ...
Federle, Mark O.
core   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

open access: yesMolecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck   +12 more
wiley   +1 more source

The Research of the Project Proprietor’ s Management Control of Engineering Change

open access: yesSHS Web of Conferences, 2015
The problem of the engineering budgetary estimate surpass engineering cost estimate, engineering budget surpass engineering budgetary estimate, engineering final accounts surpass engineering budget in our country’s present stage of the engineering ...
Pan Yanhua, Chen Yanfan
doaj   +1 more source

ORGANIZATION OF CIVIL ENGINEERING BUSINESS MANAGEMENT SYSTEM BASED ON DIGITAL TECHNOLOGY

open access: yesНаучно-технические ведомости СПбГПУ: Экономические науки, 2020
It is possible to increase effectivity in the civil engineering sector, one of the most important sectors for the Economics of Russian Federation—with digital technologies.
ustinova liliya, Roman Nicolay
doaj   +1 more source

Methodical Problems in Organic Farming Research [PDF]

open access: yes, 2002
Workshop presentation with particular focus on values, transferability and praxis relevance of organic farming research. Examples from agricultural engineering lead to the conclusion, that prototype farming, goal oriented project management ...
Schäfer, Winfried
core  

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

open access: yesMolecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié   +13 more
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

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