Results 71 to 80 of about 3,155,901 (278)

ORGANIZATION OF CIVIL ENGINEERING BUSINESS MANAGEMENT SYSTEM BASED ON DIGITAL TECHNOLOGY

Научно-технические ведомости СПбГПУ: Экономические науки, 2020
It is possible to increase effectivity in the civil engineering sector, one of the most important sectors for the Economics of Russian Federation—with digital technologies.
ustinova liliya, Roman Nicolay
doaj   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Creativity in Mass-Education Contexts [PDF]

, 2006
This paper discusses a learning framework (working title: ‘fog framework’) that has been developed in response to the challenge of teaching creative subjects in a mass-education context.
Anusas, M.
core  

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

When Engineers Become Managers: Learning from Current Engineering Managers to Advance Engineering Management Education

Proceedings of the Canadian Engineering Education Association (CEEA), 2011
This paper reports on the findings of a combined qualitative and quantitative research case study into engineering management (EM) practices in offshore Oil and Gas industry in St. John's, Newfoundland. It was designed to examine the management challenges faced by EMs in this sector, how EMs are selected, how engineers respond to being made managers ...
Paul Ryan, Leonard Lye, Amy Hsiao
openaire   +2 more sources

Redox regulation meets metabolism: targeting PRDX2 to prevent hepatocellular carcinoma

Molecular Oncology, EarlyView.
PRDX2 acts as a central redox hub linking metabolic dysfunction‐associated steatohepatitis (MASH) to hepatocellular carcinoma (HCC). In normal hepatocytes, PRDX2 maintains redox balance and metabolic homeostasis under oxidative stress. In contrast, during malignant transformation, PRDX2 promotes oncogenic signaling, stemness, and tumor initiation ...
Naroa Goikoetxea‐Usandizaga, María Luz Martinez‐Chantar, Carolina Conter   +2 more
wiley   +1 more source

PROJECT MANAGEMENT OF REVERSE ENGINEERING

Вісник Національного технічного університету «ХПÌ». Серія: Стратегічне управління, управління портфелями, програмами та проектами, 2015
It is extended the concept of reverse engineering and invited its division into three classes of problems: conceptual, aggregate and complete. The analysis of the composition of the project team, the hardware, software and heuristic methods are used in ...
Виктор Владимирович ИВАНОВ
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Valuing Knowledge Management Impact on Engineering Design Activities [PDF]

Knowledge Management Systems (KMS) have been developed in Engineering Designactivities in order to improve the productivity of these activities. Nevertheless it is still verydifficult to identify the impact of such Systems on the Engineering Design ...
Aurélie Dudezert, Mickaël Gardoni
core  

RWU Holds Steel “Topping-Off” Ceremony for Engineering, Computing & Construction Management Labs [PDF]

, 2018
Roger Williams University on Monday held a steel “topping-off” ceremony, marking completion of the steel framework for a laboratories building for RWU’s School of Engineering, Computing and Construction ...
Fitzpatrick, Edward
core   +1 more source