Results 31 to 40 of about 369,296 (265)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Improved Environmental Stimulus and Biological Competition Tactics Interactive Artificial Ecological Optimization Algorithm for Clustering

Biomimetics, 2023
An interactive artificial ecological optimization algorithm (SIAEO) based on environmental stimulus and a competition mechanism was devised to find the solution to a complex calculation, which can often become bogged down in local optimum because of the ...
Wenyan Guo, Mingfei Wu, Fang Dai, Yufan Qiang   +3 more
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

The Reformulation-Optimization Software Engine [PDF]

, 2010
Most optimization software performs numerical computation, in the sense that the main interest is to find numerical values to assign to the decision variables, e.g. a solution to an optimization problem. In mathematical programming, however, a considerable amount of symbolic transformation is essential to solving difficult optimization problems, e.g ...
Leo Liberti, Sonia Cafieri, David Savourey   +2 more
openaire   +1 more source

Linear partition heuristics for a generalized delivery workload balancing problem with an allocation of cargoes to interim storage lanes

Journal of Advanced Mechanical Design, Systems, and Manufacturing, 2019
Given m periodic deliveries performed by a single tractor and a finite set N of cargoes with their arrival times and processing times, we are asked to find a feasible partition of the cargo set N into m disjoint subsets.
Yoshiyuki KARUNO, Yutaro UOTANI
doaj   +1 more source

Gaining-Sharing Knowledge Based Algorithm With Adaptive Parameters for Engineering Optimization

IEEE Access, 2021
As optimization algorithms have a great power to solve nonlinear, complex, and hard optimization problems, nature-inspired algorithms have been applied extensively in distinct fields in order to solve real life optimization cases.
Ali Wagdy Mohamed, Hattan F. Abutarboush, Anas A. Hadi, Ali Khater Mohamed   +3 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Fast EM-driven nature-inspired optimization of antenna input characteristics using response features and variable-resolution simulation models

Scientific Reports
Utilization of optimization technique is a must in the design of contemporary antenna systems. Often, global search methods are necessary, which are associated with high computational costs when conducted at the level of full-wave electromagnetic (EM ...
Slawomir Koziel, Anna Pietrenko-Dabrowska   +1 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source