Results 31 to 40 of about 396,315 (265)

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Linear partition heuristics for a generalized delivery workload balancing problem with an allocation of cargoes to interim storage lanes

Journal of Advanced Mechanical Design, Systems, and Manufacturing, 2019
Given m periodic deliveries performed by a single tractor and a finite set N of cargoes with their arrival times and processing times, we are asked to find a feasible partition of the cargo set N into m disjoint subsets.
Yoshiyuki KARUNO, Yutaro UOTANI
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

A Novel Resource Allocation Scheme in NOMA-Based Cellular Network with D2D Communications

Future Internet, 2020
Non-orthogonal multiple access (NOMA) has become a promising technology for 5G. With the support of effective resource allocation algorithms, it can improve the spectrum resource utilization and system throughput.
Jingpu Wang, Xin Song, Yatao Ma
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

The Reformulation-Optimization Software Engine [PDF]

, 2010
Most optimization software performs numerical computation, in the sense that the main interest is to find numerical values to assign to the decision variables, e.g. a solution to an optimization problem. In mathematical programming, however, a considerable amount of symbolic transformation is essential to solving difficult optimization problems, e.g ...
Leo Liberti, Sonia Cafieri, David Savourey   +2 more
openaire   +1 more source

Fast EM-driven nature-inspired optimization of antenna input characteristics using response features and variable-resolution simulation models

Scientific Reports
Utilization of optimization technique is a must in the design of contemporary antenna systems. Often, global search methods are necessary, which are associated with high computational costs when conducted at the level of full-wave electromagnetic (EM ...
Slawomir Koziel, Anna Pietrenko-Dabrowska   +1 more
doaj   +1 more source

Dynamic Programming Algorithms with Data Rounding for Combinatorial Food Packing Problems

Journal of Advanced Mechanical Design, Systems, and Manufacturing, 2013
The lexicographic bi-criteria combinatorial food packing problem to be discussed in this paper is described as follows. Given a set I = {i | i = 1, 2, . . .
Yoshiyuki KARUNO, Kazushi TAKAHASHI, Atsushi YAMADA   +2 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source