Results 41 to 50 of about 396,315 (265)

Simultaneous Optimization of Variable Blank Holder Force Trajectory and Tools Motion in Deep Drawing via Sequential Approximate Optimization

Journal of Advanced Mechanical Design, Systems, and Manufacturing, 2012
In this paper, variable blank holder force (VBHF) trajectory and tools motion are optimized simultaneous by a sequential approximate optimization (SAO) with radial basis function (RBF) network.
Jirasak SRIRAT, Satoshi KITAYAMA, Koetsu YAMAZAKI   +2 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Compact design of a redundant manipulator system and application to multiple-goal tasks with temporal constraint

Journal of Advanced Mechanical Design, Systems, and Manufacturing, 2017
This paper aims to design a compact manipulator system consisting of a 6 degree-of-freedom (dof) manipulator and a 1-dof rotary table. It proposes a new compactness measure that considers manipulator swept volume or the space occupied by the system while
Lounell Bahoy GUETA, Ryosuke CHIBA, Tamio ARAI, Tsuyoshi UEYAMA, Jose Ildefonso Udang RUBRICO, Jun OTA   +5 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Microfluidically frequency-reconfigurable compact self-quadruplexing tunable antenna with high isolation based on substrate integrated waveguide

Scientific Reports
This communication presents a novel concept of microfluidically frequency-reconfigurable self-quadruplexing tunable antenna for quad-band applications. At the initial design stage, a substrate-integrated square cavity is divided into four unequal quarter-
Rusan Kumar Barik, Slawomir Koziel
doaj   +1 more source

Heuristic algorithms for a delivery workload balancing problem in an assembly plant

Journal of Advanced Mechanical Design, Systems, and Manufacturing, 2016
In this paper, a delivery workload balancing problem in an assembly plant is considered. The problem is first described as a special case of the unrelated parallel machine scheduling problem of minimizing the makespan.
Yoshiyuki KARUNO, Kento FURUKAWA
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Efficient Codon Optimization with Motif Engineering [PDF]

Journal of Discrete Algorithms, 2011
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Anne Condon, Chris Thachuk
openaire   +3 more sources