Results 51 to 60 of about 396,315 (265)

Adaptive Population Learning EJaya Algorithm for Real-World Optimization Problems [PDF]

International Journal of Mathematical, Engineering and Management Sciences
EJaya enhances the global exploration capability of the Jaya algorithm but still suffers from drawbacks such as local stagnation and slow convergence due to its single learning strategy and weak population maintenance. To address these issues, this paper
Sonal Deshwal, Sandeep Kumar Mogha
doaj   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Net saving improvement of capacitor banks in power distribution systems by increasing daily size switching number: A comparative result analysis by artificial intelligence

The Journal of Engineering
This paper studies the effect of the number of switching (NOS) per day of capacitor banks on loss reduction in radial distribution systems. To this aim, the daytime (more precisely, 24 h) is divided into different numbers of time segments (equal to the ...
Omid Sadeghian, Ashkan Safari
doaj   +1 more source

A HYBRID BIO-INSPIRED ALGORITHM FOR ROBUST GLOBAL OPTIMIZATION USING GAZELLE-DIFFERENTIAL EVOLUTION IN COMPLEX ENGINEERING DOMAINS [PDF]

ICTACT Journal on Soft Computing
In complex engineering systems, solving high-dimensional, nonlinear, and multimodal optimization problems remains a formidable challenge. Traditional optimization techniques often converge prematurely or fail to scale effectively with problem complexity.
V. Sabaresan, P. Kumari
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Bat algorithm based on kinetic adaptation and elite communication for engineering problems

CAAI Transactions on Intelligence Technology
The Bat algorithm, a metaheuristic optimization technique inspired by the foraging behaviour of bats, has been employed to tackle optimization problems.
Chong Yuan, Dong Zhao, Ali Asghar Heidari, Lei Liu, Shuihua Wang, Huiling Chen, Yudong Zhang   +6 more
doaj   +1 more source

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

Algorithm Engineering in Robust Optimization [PDF]

, 2016
Robust optimization is a young and emerging field of research having received a considerable increase of interest over the last decade. In this paper, we argue that the the algorithm engineering methodology fits very well to the field of robust optimization and yields a rewarding new perspective on both the current state of research and open research ...
Marc Goerigk, Anita Schöbel
openaire   +3 more sources