Results 71 to 80 of about 369,296 (265)
Analysis of empirical knowledge acquisition process in optimal design of multi-disciplinary system
Nihon Kikai Gakkai ronbunshu, 2015 Adequate optimization formulation and algorithm choices are essential for successful optimal design of a multi-disciplinary system. Details of such process remain with the realm of tacit experimental knowledge and skills of engineers.
Yutaka NOMAGUCHI +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Molecular Oncology, EarlyView.This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu +3 more
wiley +1 more source
Cooperative item collecting problems in directed bipartite structures
Journal of Advanced Mechanical Design, Systems, and Manufacturing, 2017 In this paper, a variant of 0-1 knapsack problems in graph structures is considered. Given a directed bipartite structure with a set of items and a set of players, the problem asks to find an arc reversing strategy of the players which collects items ...
Yoshiyuki KARUNO, Seiya TANAKA
doaj +1 more source
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
Journal of Advanced Mechanical Design, Systems, and Manufacturing, 2010 The present paper considers optimization of lens adjustment in semiconductor lithography equipment. For improving productivity, the laser irradiation power of recent semiconductor lithography equipment has been boosted, which causes significant ...
Yuji SHINANO +3 more
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Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
Simulation and optimization in engineering [PDF]
SIMULATION, 2019 Bin Yu, Tao Feng 0008
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Journal of Advanced Mechanical Design, Systems, and Manufacturing, 2012 Optimum segmented blank holder shape and its variable blank holder gaps (VBHGs) are determined by a sequential approximate optimization (SAO) with radial basis function network. In deep drawing, wrinkling and tearing of blank sheet are major defects. The
Jirasak SRIRAT +2 more
doaj +1 more source