Results 71 to 80 of about 396,315 (265)

Cooperative item collecting problems in directed bipartite structures

Journal of Advanced Mechanical Design, Systems, and Manufacturing, 2017
In this paper, a variant of 0-1 knapsack problems in graph structures is considered. Given a directed bipartite structure with a set of items and a set of players, the problem asks to find an arc reversing strategy of the players which collects items ...
Yoshiyuki KARUNO, Seiya TANAKA
doaj   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Optimization of Lens Adjustment in Semiconductor Lithography Equipment Using Quadratically Constrained and Second-Order Cone Programming

Journal of Advanced Mechanical Design, Systems, and Manufacturing, 2010
The present paper considers optimization of lens adjustment in semiconductor lithography equipment. For improving productivity, the laser irradiation power of recent semiconductor lithography equipment has been boosted, which causes significant ...
Yuji SHINANO, Toshiyuki YOSHIHARA, Ryuhei MIYASHIRO, Youzou FUKAGAWA   +3 more
doaj   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Optimization of Segmented Blank Holder Shape and Its Variable Blank Holder Gap in Deep-Drawing Process

Journal of Advanced Mechanical Design, Systems, and Manufacturing, 2012
Optimum segmented blank holder shape and its variable blank holder gaps (VBHGs) are determined by a sequential approximate optimization (SAO) with radial basis function network. In deep drawing, wrinkling and tearing of blank sheet are major defects. The
Jirasak SRIRAT, Koetsu YAMAZAKI, Satoshi KITAYAMA   +2 more
doaj   +1 more source

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

Molecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh, Ji Yun Jang, Yoon Jeon, Gi‐Cheon Kim, Hwanho Lee, Jooyoung Lee, Ju‐Hwa Kim, Hakhyun Kim, Minjee Kim, Ho‐Keun Kwon, Ho Lee, Hyun Seok Kim   +11 more
wiley   +1 more source

Kinematic Synthesis for Linkages with Velocity Targets

Journal of Advanced Mechanical Design, Systems, and Manufacturing, 2012
A gradient-based optimization method for designing linkages with velocity targets is described. Two theoretical application cases are established for four-bar linkage. In the first, a constant-velocity module is proposed for a point on the coupler.
Ana DE-JUAN, Ramon SANCIBRIAN, Pablo GARCÍA, Fernando VIADERO, Miguel IGLESIAS, Alfonso FERNÁNDEZ   +5 more
doaj   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Simulation and optimization in engineering [PDF]

SIMULATION, 2019
Bin Yu, Tao Feng 0008
openaire   +1 more source

A Search Algorithm for Generating Alternative Process Plans in Flexible Manufacturing System

Journal of Advanced Mechanical Design, Systems, and Manufacturing, 2007
Capabilities and complexity of manufacturing systems are increasing and striving for an integrated manufacturing environment. Availability of alternative process plans is a key factor for integration of design, process planning and scheduling. This paper
Hossein TEHRANI, Nobuhiro SUGIMURA, Yoshitaka TANIMIZU, Koji IWAMURA   +3 more
doaj   +1 more source