Results 81 to 90 of about 396,315 (265)

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Decarbonization Optimization of a Waste Heat Recovery System for Waste Tire Pyrolysis: Integrating AI-based Predictive Modeling and Thermodynamic Performance Validation

Journal of Applied Science and Engineering
20%–30% of total energy consumption in the global industrial sector is lost in the form of low-grade waste heat. The 100–200 °C exhaust waste heat generated by the pyrolysis process of waste tires has a remarkably high recovery potential, but its organic
Shih-Hsing Chang, Chin-Han Tsai, Chyan-Chyi Wu   +2 more
doaj   +1 more source

An application of the linear partition for scheduling identical jobs in a restricted cyclic production system

Journal of Advanced Mechanical Design, Systems, and Manufacturing, 2014
In this paper, we consider a combinatorial optimization problem in a cyclic production system treating identical jobs. The cyclic production system possesses m machines, and every job consists of n tasks.
Rei HINO, Yoshiyuki KARUNO
doaj   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Optimized bacteria are environmental prediction engines

Physical Review E, 2018
Experimentalists have observed phenotypic variability in isogenic bacteria populations. We explore the hypothesis that in fluctuating environments this variability is tuned to maximize a bacterium's expected log growth rate, potentially aided by epigenetic markers that store information about past environments.
Marzen, Sarah E, Crutchfield, James P
openaire   +7 more sources

Approximation algorithms for a sequencing problem with a biased bipartite structure

Journal of Advanced Mechanical Design, Systems, and Manufacturing, 2016
Given a family of m + 1 sets of n vertices in a metric space, a bi-level optimization problem to be considered in this paper asks to find a minimum cost repetitive walk with a prescribed terminal vertex.
Aleksandar SHURBEVSKI, Hiroshi NAGAMOCHI, Yoshiyuki KARUNO   +2 more
doaj   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Optimizing mechanical component design with population-based metaheuristics

Open Engineering
This study presents a comprehensive comparison of two population-based metaheuristic algorithms, differential evolution (DE) and particle swarm optimization (PSO), applied to the optimization of mechanical component design under both single-objective and
Nakkiew Warisa, Suriyanoi Sumanut, Nakkiew Wasawat, Wisittipanit Nuttachat   +3 more
doaj   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source