Results 91 to 100 of about 160,456 (265)

Electrical Engineering 3K4: Simulation and Optimization I

open access: yes, 1988
Custom courseware prepared by John Bandler for Electrical Engineering 3K4: Simulation and Optimization, for the winter 1988 term. Sections within the courseware feature primarily new material, supplemented by several sections of examples, computational ...
Bandler, John
core  

On convergence of the maximum block improvement method

open access: yes, 2015
. The MBI (maximum block improvement) method is a greedy approach to solving optimization problems where the decision variables can be grouped into a finite number of blocks. Assuming that optimizing over one block of variables while fixing all others is
Shuzhong Zhang   +5 more
core   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

open access: yesMolecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena   +15 more
wiley   +1 more source

Analysis of empirical knowledge acquisition process in optimal design of multi-disciplinary system

open access: yesNihon Kikai Gakkai ronbunshu, 2015
Adequate optimization formulation and algorithm choices are essential for successful optimal design of a multi-disciplinary system. Details of such process remain with the realm of tacit experimental knowledge and skills of engineers.
Yutaka NOMAGUCHI   +4 more
doaj   +1 more source

Short Course on Optimization Technology and Applications in High Frequency and Microwave Circuit Design

open access: yes, 1994
Course notes and advertisement for a Short Course given at the Department of Electromagnetic Theory and Engineering, Duisburg University, Duisburg, Germany. The course was delivered by John W. Bandler and S.H. Chen on October 4 and 5, 1994.
Bandler, John W.   +2 more
core  

Optimization and control methods in industrial engineering and construction

open access: yes, 2014
This book presents recent advances in optimization and control methods with applications to industrial engineering and construction management. It consists of 15 chapters authored by recognized experts in a variety of fields including control and ...
Xu, Honglei, Wang, Xiangyu
core   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

open access: yesMolecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi   +7 more
wiley   +1 more source

Optimized bacteria are environmental prediction engines

open access: yesPhysical Review E, 2018
Experimentalists have observed phenotypic variability in isogenic bacteria populations. We explore the hypothesis that in fluctuating environments this variability is tuned to maximize a bacterium's expected log growth rate, potentially aided by epigenetic markers that store information about past environments.
Marzen, Sarah E, Crutchfield, James P
openaire   +6 more sources

Surrogate-assisted evolutionary optimization frameworks for high-fidelity engineering design problems

open access: yes, 2004
Over the last decade, Evolutionary Algorithms (EAs) have emerged as a powerful paradigm for global optimization of multimodal functions. More recently, there has been significant interest in applying EAs to engineering design problems.
Wong, K.W.   +4 more
core  

Harmony Search Algorithms in Structural Engineering

open access: yes, 2011
Contemporary design in engineering and industry relies heavily on computer simulation and efficient algorithms to reduce the cost and to maximize the performance and sustainability as well as profits and energy efficiency. Solving an optimization problem
Hasançebi, Oğuzhan
core   +1 more source

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