Results 61 to 70 of about 396,315 (265)

EDECO: An Enhanced Educational Competition Optimizer for Numerical Optimization Problems

Biomimetics
The Educational Competition Optimizer (ECO) is a newly proposed human-based metaheuristic algorithm. It derives from the phenomenon of educational competition in society with good performance.
Wenkai Tang, Shangqing Shi, Zengtong Lu, Mengying Lin, Hao Cheng   +4 more
doaj   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Simultaneous optimization in plastic injection molding for weldline temperature and clamping force

Nihon Kikai Gakkai ronbunshu, 2017
In plastic injection molding (PIM), the process parameters such as melt temperature, mold temperature, injection time, and so on strongly affect the energy consumption as well as the product quality.
Kanako TAMADA, Satoshi KITAYAMA, Masahiro TAKANO, Shuji AIBA   +3 more
doaj   +1 more source

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Optimization of energy distribution in hydraulic hammer forging considering billet jumping based on the three actuals

Journal of Advanced Mechanical Design, Systems, and Manufacturing
This paper presents an optimization of energy distribution in hydraulic hammer forging based on the three actuals which are (1) actual place, (2) actual product and (3) actual situation. For the automation in the hydraulic hammer forging, “billet jumping”
Satoshi KITAYAMA, Yasunari KAWAYACHI, Masaharu AMANO, Shuhei KONDO, Eri AONO   +4 more
doaj   +1 more source

Analysis of empirical knowledge acquisition process in optimal design of multi-disciplinary system

Nihon Kikai Gakkai ronbunshu, 2015
Adequate optimization formulation and algorithm choices are essential for successful optimal design of a multi-disciplinary system. Details of such process remain with the realm of tacit experimental knowledge and skills of engineers.
Yutaka NOMAGUCHI, Hiroyuki NAKAYAMA, Haruki INOUE, Koutaro TODA, Kikuo FUJITA   +4 more
doaj   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source