Results 61 to 70 of about 551,729 (311)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Parameter Optimization and Engineering Effect of Cut-and-Fill Mining Technology

Applied Sciences
To address the limitations of existing subsidence control technologies in coal mining, this study systematically investigates the fundamental principles of cut-and-fill mining, the stability mechanism of the filling body, and the influence law of key ...
Xiaolei Lv, Zhiqiang Wang, Baowei Meng, Weiping Shi, Yaohua Yv, Changxiang Wang   +5 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Penerapan Feature Engineering dan Hyperparameter Tuning untuk Meningkatkan Akurasi Model Random Forest pada Klasifikasi Risiko Kredit

Jurnal Teknologi Informasi dan Ilmu Komputer
  Risiko kredit adalah hal yang penting untuk dianalisis di awal pengajuan kredit guna mengurangi nilai Non-Performing Loan (NPL) atau risiko gagal bayar.
Nadea Putri Nur Fauzi, Siti Khomsah, Aditya Dwi Putra Wicaksono   +2 more
doaj   +3 more sources

Physical and Engineering Parameter of Garlic

International Journal of Plant & Soil Science
Garlic is nature's most versatile medicinal plant and it is primarily used as a flavoring agent in cooking. It is the second most important spice after the onion. The physical parameter of garlic performs a crucial role in context designing of conveying systems and metering units.
Prashant M. Dikkar, Prashant M. Dsouza, Sheen C. Moses, Rana N. Aalam   +3 more
openaire   +1 more source

Solar PV parameter estimation using multi-objective optimisation

, 2019
The estimation of the electrical model parameters of solar PV, such as light-induced current, diode dark saturation current, thermal voltage, series resistance, and shunt resistance, is indispensable to predict the actual electrical performance of solar ...
Utkarsh Jadli, Nikita Rawat, Padmanabh Thakur, Rawat, N, Thakur, P, Jadli, Utkarsh, Jadli, U, Rawat, Nikita, Thakur, Padmanabh   +8 more
core   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

A numerical treatment of unsteady three-dimensional hydromagnetic flow of a Casson fluid with Hall and radiation effects

Results in Physics, 2018
The study of the unsteady magnetohydrodynamic three-dimensional radiative flow of a viscous incompressible electrically conducting Casson liquid along a stretching surface including the effects of Hall current is presented in this article. The fluid flow
Prashu, R. Nandkeolyar
doaj   +1 more source

On Parameter Tuning in Search Based Software Engineering [PDF]

, 2011
When applying search-based software engineering (SBSE) techniques one is confronted with a multitude of different parameters that need to be chosen: Which population size for a genetic algorithm? Which selection mechanism to use? What settings to use for dozens of other parameters?
Andrea Arcuri, Gordon Fraser 0001
openaire   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source