Results 81 to 90 of about 2,073,600 (331)

LC-MS Analysis of Serum for the Metabolomic Investigation of the Effects of Pulchinenoside b4 Administration in Monosodium Urate Crystal-Induced Gouty Arthritis Rat Model

Molecules, 2019
Gouty arthritis (GA) is commonly caused by deposition of monosodium urate (MSU) crystals within the joint capsule, bursa, cartilage, bone, or other periarticular tissues after chronic hyperuricemia.
Shang Lyu, Ruowen Ding, Peng Liu, Hui OuYang, Yulin Feng, Yi Rao, Shilin Yang   +6 more
doaj   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Engineering Students’ Perceptions of their Preparation for Engineering Practice

, 2015
A common theme in the scholarly literature describing engineering is associated with the conception of the term global engineer where the role of the engineer has become quite broad. This study investigates engineering students’ perceptions of their future careers and their preparation for professional practice.
openaire   +2 more sources

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Study on particle fluidization characteristics and separation effect of coarse slime fluidized flotation

Meitan kexue jishu
The new gas-liquid-solid fluidized bed flotation technology can realize the efficiency recovery of coarse particles based on the principle of refloating coupling.
Qinglin YIN, Shihao DING, Yiqing ZHANG, Qi HE, Yaowen XING, Xiahui GUI   +5 more
doaj   +1 more source

Information Literacy Instruction for Upper-Year Undergraduate Students: A Stratified Course-Integrated Approach [PDF]

, 2013
Undergraduate students face many potential barriers to learning about the process of conducting research. Information literacy instruction provided through faculty-librarian collaboration in an effort to expand the abilities of the “novice researcher ...
Nordlund, Stacey
core   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Construction and optimization of a genetic transformation system for efficient expression of human insulin-GFP fusion gene in flax

Bioresources and Bioprocessing
The human insulin gene modified with a C-peptide was synthesized according to the plant-preferred codon, and a fusion gene expression vector of insulin combined with green fluorescent protein (GFP) was constructed.
Wei Zhao, Rui Zhang, Luyang Zhou, Zhongxia Zhang, Fei Du, Ruoyu Wu, Jing Kong, Shengjun An   +7 more
doaj   +1 more source

Science and applications of wafer-scale crystalline carbon nanotube films prepared through controlled vacuum filtration

, 2018
Carbon nanotubes (CNTs) make an ideal one-dimensional (1D) material platform for the exploration of exotic physical phenomena under extremely strong quantum confinement.
Gao, Weilu, Kono, Junichiro
core   +1 more source