Results 91 to 100 of about 784,364 (310)

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

open access: yesFEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas   +6 more
wiley   +1 more source

数据科学与工程:大数据时代的新兴交叉学科

open access: yes大数据, 2015
There are some characteristics for IT development in the big data era:the real-life applications are the driving force for innovation; open sourcing accelerates innovation,and the advancement in hardware lay the foundation for innovation.The data ...
Aoying Zhou, Weining Qian, Changbo Wang
doaj  

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

open access: yesFEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Proceedings of First Conference for Engineering Sciences and Technology: Vol. 1 [PDF]

open access: yes, 2018
This volume contains contributed articles of Track 1, Track 2 & Track 3, presented in the conference CEST-2018, organized by Faculty of Engineering Garaboulli, and Faculty of Engineering, Al-khoms, Elmergib University (Libya) on 25-27 September ...
Basher, Tariq; Department of Petroleum Engineering, College of Engineering, Sirte University, Libya   +84 more
core   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

open access: yesFEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Thermal insulation of wet shielded metal arc welds [PDF]

open access: yes, 1993
Thesis (Nav. E.)--Massachusetts Institute of Technology, Dept. of Ocean Engineering, 1994, and Thesis (M.S.)--Massachusetts Institute of Technology, Dept.
Keenan, Patrick Joseph.   +1 more
core  

HUMANITIES AND INTELLECTUAL ENVIRONMENTS

open access: yesВысшее образование в России, 2016
The article considers different approaches to teaching humanities and social sciences at higher schools of engineering and technology. Analyzing “minimalist” and “extended” approaches, which the author finds in this field, he defines and then compares ...
Andrey L. Andreev
doaj  

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

open access: yesFEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson   +6 more
wiley   +1 more source

Teaching Staff Awareness and Use of Infographic Technology in the School of Engineering, Computer and Mathematical Sciences [PDF]

open access: yes, 2019
Teachers are probably the most important factor in the educational process because of their role in organising students’ learning experiences. Future teachers require high levels of information, knowledge and skills to enable them to perform successfully
Al-Tukruni, Elham
core  

Convergences, transferts et intégrations entre sciences du langage, sciences et ingénierie en temps de guerre et de guerre froide (1941-1966)

open access: yesRevue d’Histoire des Sciences Humaines, 2015
This paper aims at examining the impact of war sciences on language sciences during the World War II. I will assume that the interaction between war sciences (engineering and sciences) and language sciences should be distinguished from the war effort ...
Jacqueline Léon
doaj   +1 more source

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