Results 121 to 130 of about 784,364 (310)

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Bolted joint studies in GRP [PDF]

, 1994
Thesis (Nav. E.)--Massachusetts Institute of Technology, Dept. of Ocean Engineering, 1994, and Thesis (M.S.)--Massachusetts Institute of Technology, Dept.
Fox, David M. (David Michael)
core  

Mathematics as a Gateway, Not a Barrier: Reimagining Engineering Preparation for the 21st Century

Education Sciences
For more than seventy years, mathematics—particularly the calculus sequence—has defined both the rigor and the exclusivity of engineering education in the United States. While this structure was historically instrumental in professionalizing engineering,
Jenna Carpenter, Nathan Klingbeil, Sheryl Sorby, Gary Bertoline   +3 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Near field three-dimensional coded aperture techniques : theoretical and experimental exploration for applications in imaging and detection systems [PDF]

, 1998
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Nuclear Engineering; and, Harvard-MIT Division of Health Sciences and Technology, 1998.Includes bibliographical references (leaves 149-154).by Li Zhang.Ph ...
Zhang, Li
core  

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Gendered occupational differences in science, engineering, and technology careers [PDF]

, 2012
Gender segregation is an issue that still exists in today’s society. With the dominance of men in the science, engineering, and technology sectors, there is still a question of the underrepresentation of women.
Bogg, Jan, Prescott, Julie
core  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Breaking bridges between Sciences, Engineering and Business Management [PDF]

, 2010
The 2nd International Conference on the Roles of Humanities and Social Science in Engineering (ICoHSE 2010) organized by Universiti Malaysia Perlis (UniMAP), 12th - 14th November 2010 at Bayview Beach Resort, Penang, Malaysia.In today’s world, management
M-Said, Oukil
core  

Prospects of urban biotechnology for ornamental plants

City and Environment Interactions
Plant biotechnology methods can be used in urban environments. Cell selection, genetic engineering, and micropropagation hold great promise among biotechnological methods.
Evgeny Aleksandrovich Gladkov, Olga Victorovna Gladkova   +1 more
doaj   +1 more source