Results 41 to 50 of about 703,793 (262)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Correction to: Simultaneous Resistance of Bacteria to Antibiotics and Disinfectants: A Threat to Vulnerable Patients in Intensive Care Units [PDF]

Journal of Mazandaran University of Medical Sciences
Mina Sheikh1, Sahar Gholipour2, Zahra Mirhendi3, Mahnaz Nikaeen4 1 PhD Student, Department of Environmental Health Engineering, School of Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran 2 Post Doctoral Researcher, Department of ...
Mina Sheikh, Sahar Gholipour, Zahra Mirhendi, Mahnaz Nikaeen   +3 more
doaj  

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Abstracts of the 5th International Electronic Conference on Applied Sciences

Engineering Proceedings
The 5th International Electronic Conference on Applied Sciences (ASEC 2024) was held online from 4 to 6 December 2024. It represents an opportunity to gather an interdisciplinary community to discuss applied sciences. More specifically, after the success
Nunzio Cennamo, Stefano Toldo
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Reform and practice of the interdisciplinary competency cultivation model based on the German economic engineering talent training

Cogent Education
Engineering talent cultivation requires a balance of systemic knowledge, interdisciplinary understanding, and practicality skills. German economic engineering programs, centered on a ‘technology-science-humanities’ training model, have successfully ...
Fan Jiajing, Yang Zhiwei, Dai Qin
doaj   +1 more source

Cell-Seeded Biomaterial Scaffolds: The Urgent Need for Unanswered Accelerated Angiogenesis

International Journal of Nanomedicine, 2022
Hanieh Shokrani,1,* Amirhossein Shokrani,2,* S Mohammad Sajadi,3,4 Farzad Seidi,5 Amin Hamed Mashhadzadeh,6 Navid Rabiee,7,8 Mohammad Reza Saeb,9 Tejraj Aminabhavi,10,11 Thomas J Webster12,13 1Department of Chemical Engineering, Sharif University
Shokrani H, Shokrani A, Sajadi SM, Seidi F, Mashhadzadeh AH, Rabiee N, Saeb MR, Aminabhavi T, Webster TJ   +8 more
doaj  

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source