Results 61 to 70 of about 1,590,550 (317)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Readers, readers, writers and engineers [PDF]

, 2005
Extended review of books <i>Knowledge, Power and Learning</i> and <i>Learning, Space and Identity</i>, both ed. Carrie Paechter et al., Paul Chapman Publishing (2001).
Gray, N.
core  

Termites: Soil engineers for ecological engineering

Comptes Rendus. Biologies, 2019
This communication assesses advances in our knowledge of the beneficial influences of termites on ecosystem functioning and services. Termites are amongst the main macroinvertebrate decomposers in arid and semi-arid environments and exert additional impacts through the creation of biostructures (mounds, galleries, sheetings, etc.) with ...
Jouquet, Pascal, Harit, Ajay, Cheik, Sougueh, Traoré, Saran, Bottinelli, Nicolas   +4 more
openaire   +3 more sources

Structural insights into lacto‐N‐biose I recognition by a family 32 carbohydrate‐binding module from Bifidobacterium bifidum

FEBS Letters, EarlyView.
Bifidobacterium bifidum establishes symbiosis with infants by metabolizing lacto‐N‐biose I (LNB) from human milk oligosaccharides (HMOs). The extracellular multidomain enzyme LnbB drives this process, releasing LNB via its catalytic glycoside hydrolase family 20 (GH20) lacto‐N‐biosidase domain.
Xinzhe Zhang, Naoki Sunagawa, Toma Kashima, Kiyohiko Igarashi, Akimasa Miyanaga, Shinya Fushinobu   +5 more
wiley   +1 more source

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Knowledge Engineering for Non-engineers [PDF]

, 2010
This paper presents one approach for the innovative organization training for business analysts in developing enterprise ontologies. The underlying teaching framework is pursuing a methodology that will aid the process of knowledge structuring and practical ontology design, with emphasis on visual techniques.
openaire   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Impact of Stressors/Stress on Organizational Commitment of Engineers in the Construction Industry

Buildings
Engineers often play vital roles in technical planning, designing, and operating projects, as well as implementing standard requirements in the physical sites.
Mei-Yung Leung, Khursheed Ahmed, Isabella Y. S. Chan   +2 more
doaj   +1 more source

Spaces of interdisciplinary in/congruity: the coming together of engineers and social scientists in planning for sustainable urban environments

International Journal of Urban Sustainable Development, 2020
In the context of a globalised interdisciplinary moment, where boundary-crossing research collaborations are valorised, this paper considers encounters between multidisciplinary researchers.
Sophie Hadfield-Hill, John Horton, Peter Kraftl, José Antônio Perrella Balestieri, Mateus Ricardo Nogueira Vilanova, Rubens Alves Dias, Paulo Valladares Soares   +6 more
doaj   +1 more source