Results 211 to 220 of about 4,806,683 (407)

Neuid: A Novel Neuron‐Enriched LncRNA that Connects Epigenetic Gene Silencing to Alzheimer's Disease

Advanced Science, EarlyView.
ABSTRACT The increasing evidence that non‐coding RNAs can become deregulated during pathogenesis is dramatically expanding the space for drug discovery beyond the protein‐coding genome. Long noncoding RNAs (lncRNAs) are emerging as key regulators of cellular function, yet most remain uncharacterized.
Ranjit Pradhan, Zorica Petrovic, M. Sadman Sakib, Sophie Schröder, Dennis Manfred Krüger, Tonatiuh Pena, Eren Diniz, Susanne Burkhardt, Anna‐Lena Schütz, Verena Gisa, Iga Grzadzielewska, Karl Toischer, Thor D. Stein, Jan Krzysztof Blusztajn, Ivana Delalle, Jelena Radulovic, Farahnaz Sananbenesi, Andre Fischer   +17 more
wiley   +1 more source

NDTMS Themed Report NDTMS themed report: Patterns of mortality amongst injecting and non-injecting drug users in contact with treatment services in the North West of England, 2003/04-2005/06

, 2007
Ayesha Hurst, Caryl Beynon, Sara Jane Helen Hughes, Adam Marr, Jim McVeigh   +4 more
openalex   +1 more source

Embedded CRISPRi Enhances Gene‐Silencing Efficiency in Drosophila

Advanced Science, EarlyView.
Current CRISPR interference (CRISPRi) technology in Drosophila has limited efficiency. This study introduces the emCRISPRi platform, which significantly enhances transcriptional silencing efficacy by embedding inhibitory domains within the dCas9 architecture.
Pengchong Fu, Xuedi Zhang, Ying Zhou, Jie Zheng, Angyang Sun, Kailong Zhuang, Weiwei Bao, Guanjun Gao   +7 more
wiley   +1 more source

Increase of early-onset colorectal cancer: a cohort effect. [PDF]

J Natl Cancer Inst
Downham L, Laversanne M, Perdomo S, Filho AM, Bray F, Brennan P.   +5 more
europepmc   +1 more source

The taste of place: local and regional foods transform the Northeast [PDF]

Northeast farmers and consumers cooperating to make agriculture survive.Agriculture - New England ; Farm produce - New ...
Roger Doiron
core  

An Open‐Source Pipeline for Calcium Imaging and All‐Optical Physiology in Human Stem Cell‐Derived Neurons

Advanced Science, EarlyView.
This work introduces an open‐source all‐optical platform for functional phenotyping of human stem cell‐derived neurons. The system integrates optogenetics, calcium imaging, automated acquisition, and analysis to resolve single‐cell and network activity, enabling longitudinal measurements, disease modeling, and pharmacological screening in preclinical ...
Wardiya Afshar‐Saber, Federico M. Gasparoli, Ziqin Yang, Nicole A. Teaney, Rachel Hobson, Lahin Lalani, Gayathri Srinivasan, Dosh Whye, Ranit Karmakar, Elizabeth D. Buttermore, Kellen D. Winden, Cidi Chen, Mustafa Sahin   +12 more
wiley   +1 more source

Turnpike Road map for England and Wales 1700 to 1838

Alan Rosevear, Dan Bogart, Leigh Shaw‐Taylor, Max Satchell   +3 more
openalex   +1 more source

CRP Deficiency Rescues Periodontitis‐Induced Hippocampal Neurogenesis Impairment by Suppressing OPC‐Derived BMP4 Signaling in Rats

Advanced Science, EarlyView.
Chronic periodontitis elevates circulating CRP, which enters the hippocampus to upregulate BMP4 in oligodendrocyte precursor cells (OPCs), thereby impairing neurogenesis and inducing anxiety/depression‐like behaviors in rats. Counteracting this pathway, CRP deficiency helps confer functional resilience to OPCs.
Lingjie Li, Ping Deng, Siyu Hou, Xianbo Xia, Wei Zhao, Xingyu Zhu, Yang Zhang, Chao Wang, Ling Xu, Jinlin Song   +9 more
wiley   +1 more source

"The best way we can stop suicides is by making lives worth living": a mixed-methods survey in the UK of perspectives on suicide prevention from the autism community. [PDF]

EClinicalMedicine
Moseley RL, Marsden SJ, Pelton M, Weir E, Procyshyn T, Allison CL, Parsons TA, Cassidy S, Chikaura T, Hodges H, Mosse D, Rodgers J, Hall I, Owens L, Cheyette J, Crichton D, Hedley D, Baron-Cohen S.   +17 more
europepmc   +1 more source

Robert Garnier in Elizabethan England: Mary Sidney Herbert’s <i>Antonius</i> and Thomas Kyd’s <i>Cornelia</i>

, 2019
Marie-Alice Belle, Line Cottegnies, Luke Arnason   +2 more
openalex   +2 more sources