Results 61 to 70 of about 4,724,242 (392)

Screening for lung cancer: A systematic review of overdiagnosis and its implications

open access: yesMolecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz   +12 more
wiley   +1 more source

FOREIGN LOAN POLICY OF PAUL I

open access: yesВестник Кемеровского государственного университета, 2017
This article analyzes the development of the external state debt of the Russian Empire during the reign of Paul I. That period was marked by dynamic processes in Russia's foreign policy in general and in the development of its foreign debt in particular.
Oleg V. Baev
doaj   +1 more source

Design of conditions for emergence of self-replicators

open access: yes, 2018
A self-replicator is usually understood to be an object of definite form that promotes the conversion of materials in its environment into a nearly identical copy of itself.
England, Jeremy L., Sarkar, Sumantra
core   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

open access: yesMolecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir   +12 more
wiley   +1 more source

Anti-White Slavery Legislation and its Legacies in England

open access: yesAnti-Trafficking Review, 2017
This paper argues that the foundation of modern anti-trafficking laws in England and Wales was created at the turn of the twentieth century, during the peak of white slavery hysteria. It shows that a series of interrelated legal interventions formed that
Laura Lammasniemi
doaj   +1 more source

A new pliosaurid from the Oxford Clay Formation of Oxfordshire, UK

open access: yesActa Palaeontologica Polonica, 2022
We describe the anatomy of a new longirostrine pliosaurid, Eardasaurus powelli gen. et sp. nov., based on a substantially complete skeleton from the Middle Jurassic Oxford Clay Formation of Oxfordshire, UK.
HILARY F. KETCHUM, ROGER B.J. BENSON
doaj   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

open access: yesMolecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz   +15 more
wiley   +1 more source

English Financiers of the Middle of the XIV Century: Features and Results of Activity

open access: yesНаучный диалог, 2021
The article examines the features of the country’s economic and political development in the second third of the XIV century through the prism of analyzing the activities of famous representatives of the commercial and financial stratum of England.
O. V. Yablonskaya
doaj   +1 more source

An implementation of Sub-CAD in Maple [PDF]

open access: yes, 2015
Cylindrical algebraic decomposition (CAD) is an important tool for the investigation of semi-algebraic sets, with applications in algebraic geometry and beyond.
England, Matthew, Wilson, David
core   +3 more sources

The psychological temperament of Anglican clergy in ordained local ministry (OLM) : the conserving, serving pastor? [PDF]

open access: yes, 2012
This study draws on psychological type theory as originally proposed by Jung (1971) and psychological temperament theory as proposed by Keirsey and Bates (1978) to explore the hypothesis that ordained local ministers (OLMs) within the Church of England ...
Francis, Leslie J., Village, Andrew
core   +1 more source

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